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YKL40 elisa kit :: Fish Cartilage Glycoprotein 39/Ykl40 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005626 YKL40 elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cartilage Glycoprotein 39/Ykl40, ELISA Kit

 Also Known As   

Fish Cartilage Glycoprotein 39/Ykl40 ELISA Kit

 Product Gene Name   

YKL40 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    601525
 3D Structure    ModBase 3D Structure for P36222
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of YKL40 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for YKL40 purchase    MBS005626 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cartilage Glycoprotein 39/Ykl40, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing YKL40. The ELISA analytical biochemical technique of the MBS005626 kit is based on YKL40 antibody-YKL40 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect YKL40 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, YKL40. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for YKL40. It may not necessarily be applicable to this product.
 NCBI GI #    144226251
 NCBI GeneID    1116
 NCBI Accession #    NP_001267.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276.2 [Other Products]
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 UniProt Primary Accession #    P36222 [Other Products]
 UniProt Secondary Accession #    P30923; Q8IVA4; Q96HI7; B2R7B0 [Other Products]
 UniProt Related Accession #    P36222 [Other Products]
 Molecular Weight    42,625 Da
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 NCBI Official Full Name    chitinase-3-like protein 1
 NCBI Official Synonym Full Names    chitinase 3-like 1 (cartilage glycoprotein-39)
 NCBI Official Symbol    CHI3L1 [Similar Products]
 NCBI Official Synonym Symbols   
GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39
[Similar Products]
 NCBI Protein Information    chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39
 UniProt Protein Name    Chitinase-3-like protein 1
 UniProt Synonym Protein Names   
39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40
 UniProt Gene Name    CHI3L1 [Similar Products]
 UniProt Synonym Gene Names    CGP-39; GP-39; hCGP-39 [Similar Products]
 UniProt Entry Name    CH3L1_HUMAN
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 NCBI Summary for YKL40    Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
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 UniProt Comments for YKL40    CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm

Molecular Function: extracellular matrix structural constituent; chitin binding; chitinase activity; carbohydrate binding

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; response to mechanical stimulus; cartilage development; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development

Disease: Schizophrenia; Asthma-related Traits, Susceptibility To, 7
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 Research Articles on YKL40    1. Elevated pretransplant serum YKL-40 concentration is associated with bronchiolitis obliterans development and could be an independent biomarker in early prediction and monitoring of BOS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with YKL40 elisa kitDiseases associated with YKL40 elisa kit
 Reference Product  PubMed Publications
 TNF elisa kit  >26 publications with YKL40 and TNF
 STAT3 elisa kit  >5 publications with YKL40 and STAT3
 IL6 elisa kit  >5 publications with YKL40 and IL6
 VEGFA elisa kit  >3 publications with YKL40 and VEGFA
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >173 publications with YKL40 and Inflammation
 Neoplasms Antibodies  >144 publications with YKL40 and Neoplasms
 Lung Diseases Antibodies  >75 publications with YKL40 and Lung Diseases
 Nervous System Diseases Antibodies  >58 publications with YKL40 and Nervous System Diseases
 Fibrosis Antibodies  >55 publications with YKL40 and Fibrosis
 Brain Diseases Antibodies  >48 publications with YKL40 and Brain Diseases
 Osteoarthritis Antibodies  >46 publications with YKL40 and Osteoarthritis
 Skin Diseases Antibodies  >40 publications with YKL40 and Skin Diseases
 Glioma Antibodies  >40 publications with YKL40 and Glioma
 Liver Diseases Antibodies  >39 publications with YKL40 and Liver Diseases
Organs/Tissues associated with YKL40 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >321 publications with YKL40 and Blood
 Brain Antibodies  >64 publications with YKL40 and Brain
 Eye Antibodies  >9 publications with YKL40 and Eye
 Pancreas Antibodies  >3 publications with YKL40 and Pancreas
 Ovary Antibodies  >1 publications with YKL40 and Ovary
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