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COMT elisa kit :: Fish Catechol-O-Metthyhransferase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005657 COMT elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Catechol-O-Metthyhransferase (COMT), ELISA Kit

 Also Known As   

Fish Catechol-O-Metthyhransferase ELISA Kit

 Product Gene Name   

COMT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 22; NC_000022.10 (19929263..19957498). Location: 22q11.21
 OMIM    103780
 3D Structure    ModBase 3D Structure for P21964
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COMT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COMT purchase    MBS005657 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Catechol-O-Metthyhransferase (COMT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COMT. The ELISA analytical biochemical technique of the MBS005657 kit is based on COMT antibody-COMT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COMT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COMT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COMT. It may not necessarily be applicable to this product.
 NCBI GI #    47678375
 NCBI GeneID    1312
 NCBI Accession #    CAG30308.1 [Other Products]
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 UniProt Primary Accession #    P21964 [Other Products]
 UniProt Secondary Accession #    Q6IB07; Q6ICE6; A8MPV9 [Other Products]
 UniProt Related Accession #    P21964 [Other Products]
 Molecular Weight    30,037 Da
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 NCBI Official Full Name    COMT
 NCBI Official Synonym Full Names    catechol-O-methyltransferase
 NCBI Official Symbol    COMT [Similar Products]
 NCBI Protein Information    catechol O-methyltransferase
 UniProt Protein Name    Catechol O-methyltransferase
 Protein Family    Catechol O-methyltransferase
 UniProt Gene Name    COMT [Similar Products]
 UniProt Entry Name    COMT_HUMAN
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 NCBI Summary for COMT    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
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 UniProt Comments for COMT    COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 2.1.1.6; Amino Acid Metabolism - tyrosine; Methyltransferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: postsynaptic membrane; membrane; mitochondrion; axon; plasma membrane; integral to membrane; dendritic spine; cytosol

Molecular Function: protein binding; magnesium ion binding; catechol O-methyltransferase activity; O-methyltransferase activity

Biological Process: response to drug; methylation; estrogen metabolic process; cellular response to phosphate starvation; neurotransmitter catabolic process; dopamine catabolic process; negative regulation of smooth muscle cell proliferation; short-term memory; response to lipopolysaccharide; response to pain; learning; female pregnancy; reproductive process in a multicellular organism; positive regulation of homocysteine metabolic process; response to organic cyclic substance; negative regulation of dopamine metabolic process; synaptic transmission; xenobiotic metabolic process; regulation of sensory perception of pain; developmental process; neurotransmitter biosynthetic process

Disease: Schizophrenia; Panic Disorder 1
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 Research Articles on COMT    1. the COMT Val/Val genotype was associated with a greater improvement in smoking cessation using Nicotine replacement treatment
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COMT elisa kitPathways associated with COMT elisa kit
 Reference Product  PubMed Publications
 CYP1B1 elisa kit  >113 publications with COMT and CYP1B1
 CYP1A1 elisa kit  >99 publications with COMT and CYP1A1
 MAOA elisa kit  >82 publications with COMT and MAOA
 DBH elisa kit  >68 publications with COMT and DBH
 PNMT elisa kit  >29 publications with COMT and PNMT
 DDC elisa kit  >27 publications with COMT and DDC
 MAOB elisa kit  >27 publications with COMT and MAOB
 UGT1A1 elisa kit  >13 publications with COMT and UGT1A1
 UGT1A9 elisa kit  >4 publications with COMT and UGT1A9
 UGT1A8 elisa kit  >3 publications with COMT and UGT1A8
 Products by Pathway  Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Dopamine Clearance From The Synaptic Cleft Pathway antibodies  Dopamine Clearance From The Synaptic Cleft Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway antibodies  Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway Diagram
 Enzymatic Degradation Of Dopamine By COMT Pathway antibodies  Enzymatic Degradation Of Dopamine By COMT Pathway Diagram
 Estrogen Metabolism Pathway antibodies  Estrogen Metabolism Pathway Diagram
 L-dopa Degradation Pathway antibodies  L-dopa Degradation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with COMT elisa kitOrgans/Tissues associated with COMT elisa kit
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >902 publications with COMT and Mental Disorders
 Nervous System Diseases Antibodies  >585 publications with COMT and Nervous System Diseases
 Schizophrenia Antibodies  >446 publications with COMT and Schizophrenia
 Movement Disorders Antibodies  >379 publications with COMT and Movement Disorders
 Parkinson Disease Antibodies  >343 publications with COMT and Parkinson Disease
 Breast Neoplasms Antibodies  >146 publications with COMT and Breast Neoplasms
 Cognition Disorders Antibodies  >138 publications with COMT and Cognition Disorders
 Pain Antibodies  >134 publications with COMT and Pain
 Cardiovascular Diseases Antibodies  >133 publications with COMT and Cardiovascular Diseases
 Bipolar Disorder Antibodies  >115 publications with COMT and Bipolar Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >940 publications with COMT and Brain
 Blood Antibodies  >610 publications with COMT and Blood
 Liver Antibodies  >239 publications with COMT and Liver
 Nerve Antibodies  >135 publications with COMT and Nerve
 Muscle Antibodies  >131 publications with COMT and Muscle
 Heart Antibodies  >123 publications with COMT and Heart
 Vascular Antibodies  >117 publications with COMT and Vascular
 Kidney Antibodies  >95 publications with COMT and Kidney
 Lung Antibodies  >45 publications with COMT and Lung
 Adrenal Gland Antibodies  >39 publications with COMT and Adrenal Gland
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