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CLA elisa kit :: Fish Collagen Autoantibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016214 CLA elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Autoantibody (CLA), ELISA Kit

 Also Known As   

Fish Collagen Autoantibody ELISA Kit

 Product Gene Name   

CLA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    610004
 3D Structure    ModBase 3D Structure for Q9BXS0
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CLA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CLA purchase    MBS016214 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Autoantibody (CLA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLA. The ELISA analytical biochemical technique of the MBS016214 kit is based on CLA antibody-CLA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CLA. It may not necessarily be applicable to this product.
 NCBI GI #    38570075
 NCBI GeneID    84570
 NCBI Accession #    NP_942014.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_198721.3 [Other Products]
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 UniProt Primary Accession #    Q9BXS0 [Other Products]
 UniProt Secondary Accession #    Q9BXR9; A8MPZ6 [Other Products]
 UniProt Related Accession #    Q9BXS0 [Other Products]
 Molecular Weight    64,771 Da
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 NCBI Official Full Name    collagen alpha-1(XXV) chain isoform 1
 NCBI Official Synonym Full Names    collagen, type XXV, alpha 1
 NCBI Official Symbol    COL25A1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    collagen alpha-1(XXV) chain; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component
 UniProt Protein Name    Collagen alpha-1(XXV) chain
 UniProt Synonym Protein Names   
Alzheimer disease amyloid-associated protein; AMY; CLAC-P
 Protein Family    Ribonuclease clavin
 UniProt Gene Name    COL25A1 [Similar Products]
 UniProt Synonym Gene Names    AMY; CLAC [Similar Products]
 UniProt Entry Name    COPA1_HUMAN
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 NCBI Summary for CLA    This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for CLA    COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space; collagen; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane; extracellular region

Molecular Function: heparin binding; beta-amyloid binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis

Disease: Fibrosis Of Extraocular Muscles, Congenital, 5
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 Research Articles on CLA    1. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CLA elisa kitDiseases associated with CLA elisa kit
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >1 publications with CLA and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with CLA and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with CLA and Abnormalities, Multiple
 Uterine Cervical Neoplasms Antibodies  >1 publications with CLA and Uterine Cervical Neoplasms
Organs/Tissues associated with CLA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with CLA and Brain
 Muscle Antibodies  >1 publications with CLA and Muscle
 Kidney Antibodies  >1 publications with CLA and Kidney
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