NP_000085.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
295,220 Da
NCBI Official Full Name
collagen alpha-1(VII) chain
NCBI Official Synonym Full Names
collagen, type VII, alpha 1
NCBI Protein Information
collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide
UniProt Protein Name
Collagen alpha-1(VII) chain
UniProt Synonym Protein Names
Long-chain collagen
UniProt Synonym Gene Names
UniProt Entry Name
CO7A1_HUMAN
NCBI Summary for COL7
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
UniProt Comments for COL7
COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: extracellular matrix; extracellular space; collagen type VII; endoplasmic reticulum lumen; extracellular region; basement membrane
Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding
Biological Process: collagen catabolic process; extracellular matrix disassembly; epidermis development; extracellular matrix organization and biogenesis; cell adhesion
Disease: Transient Bullous Dermolysis Of The Newborn; Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Nail Disorder, Nonsyndromic Congenital, 8; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails
Research Articles on COL7
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Products associated with COL7 elisa kit
Pathways associated with COL7 elisa kit
Diseases associated with COL7 elisa kit
Organs/Tissues associated with COL7 elisa kit
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