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COL17 elisa kit :: Fish Collagen Type XVII ELISA Kit

Scan QR to view Datasheet Catalog #    MBS035217 COL17 elisa kit
Unit / Price
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 Product Name   

Collagen Type XVII (COL17), ELISA Kit

 Also Known As   

Fish Collagen Type XVII ELISA Kit

 Product Gene Name   

COL17 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    113811
 3D Structure    ModBase 3D Structure for Q9UMD9
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL17 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL17 purchase    MBS035217 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type XVII (COL17) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL17. The ELISA analytical biochemical technique of the MBS035217 kit is based on COL17 antibody-COL17 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL17 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL17. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COL17. It may not necessarily be applicable to this product.
 NCBI GI #    119829187
 NCBI GeneID    1308
 NCBI Accession #    NP_000485.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000494.3 [Other Products]
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 UniProt Primary Accession #    Q9UMD9 [Other Products]
 UniProt Secondary Accession #    Q02802; Q5JV36; Q99018; Q9NQK9; Q9UC14 [Other Products]
 UniProt Related Accession #    Q9UMD9 [Other Products]
 Molecular Weight    150,419 Da
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 NCBI Official Full Name    collagen alpha-1(XVII) chain
 NCBI Official Synonym Full Names    collagen, type XVII, alpha 1
 NCBI Official Symbol    COL17A1 [Similar Products]
 NCBI Official Synonym Symbols   
BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
[Similar Products]
 NCBI Protein Information    collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180))
 UniProt Protein Name    Collagen alpha-1(XVII) chain
 UniProt Synonym Protein Names   
180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2Cleaved into the following 2 chains:120 kDa linear IgA disease antigen; Alternative name(s):; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-197 kDa linear IgA disease antigen; Alternative name(s):; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa
 UniProt Gene Name    COL17A1 [Similar Products]
 UniProt Synonym Gene Names    BP180; BPAG2; LAD-1; 97 kDa LAD antigen; 97-LAD; LABD97 [Similar Products]
 UniProt Entry Name    COHA1_HUMAN
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 NCBI Summary for COL17    This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COL17    COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: collagen; hemidesmosome; endoplasmic reticulum lumen; integral to plasma membrane; extracellular region; plasma membrane; basement membrane; intercellular junction

Molecular Function: protein binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; epidermis development; extracellular matrix organization and biogenesis; hemidesmosome assembly; cell-matrix adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type
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 Research Articles on COL17    1. Missense mutation R1303Q in COL17a1 causes junctional epidermolysis bullosa phenotype similar to Kindler syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COL17 elisa kitPathways associated with COL17 elisa kit
 Reference Product  PubMed Publications
 DST elisa kit  >17 publications with COL17 and DST
 LAMB3 elisa kit  >15 publications with COL17 and LAMB3
 LAMC2 elisa kit  >9 publications with COL17 and LAMC2
 ITGB4 elisa kit  >6 publications with COL17 and ITGB4
 COL7A1 elisa kit  >5 publications with COL17 and COL7A1
 PLEC elisa kit  >1 publications with COL17 and PLEC
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with COL17 elisa kitOrgans/Tissues associated with COL17 elisa kit
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >49 publications with COL17 and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >8 publications with COL17 and Carcinoma, Squamous Cell
 Neoplasms Antibodies  >5 publications with COL17 and Neoplasms
 Hyperplasia Antibodies  >2 publications with COL17 and Hyperplasia
 Melanoma Antibodies  >1 publications with COL17 and Melanoma
 Fetal Death Antibodies  >1 publications with COL17 and Fetal Death
 Nervous System Malformations Antibodies  >1 publications with COL17 and Nervous System Malformations
 Cell Transformation, Neoplastic Antibodies  >1 publications with COL17 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >3 publications with COL17 and Mouth
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