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GZMS-B elisa kit :: Fish Granzymes B ELISA Kit

Scan QR to view Datasheet Catalog #    MBS007438 GZMS-B elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Granzymes B (GZMS-B), ELISA Kit

 Also Known As   

Fish Granzymes B ELISA Kit

 Product Gene Name   

GZMS-B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 14; NC_000014.8 (25100160..25103432, complement). Location: 14q11.2
 OMIM    123910
 3D Structure    ModBase 3D Structure for P10144
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GZMS-B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GZMS-B purchase    MBS007438 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Granzymes B (GZMS-B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GZMS-B. The ELISA analytical biochemical technique of the MBS007438 kit is based on GZMS-B antibody-GZMS-B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GZMS-B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GZMS-B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GZMS-B. It may not necessarily be applicable to this product.
 NCBI GI #    221625528
 NCBI GeneID    3002
 NCBI Accession #    NP_004122.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004131.4 [Other Products]
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 UniProt Primary Accession #    P10144 [Other Products]
 UniProt Secondary Accession #    Q8N1D2; Q9UCC1 [Other Products]
 UniProt Related Accession #    P10144 [Other Products]
 Molecular Weight    27,716 Da
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 NCBI Official Full Name    granzyme B
 NCBI Official Synonym Full Names    granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 NCBI Official Symbol    GZMB [Similar Products]
 NCBI Official Synonym Symbols   
HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
[Similar Products]
 NCBI Protein Information    granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2
 UniProt Protein Name    Granzyme B
 UniProt Synonym Protein Names   
C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
 UniProt Gene Name    GZMB [Similar Products]
 UniProt Synonym Gene Names    CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP [Similar Products]
 UniProt Entry Name    GRAB_HUMAN
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 NCBI Summary for GZMS-B    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GZMS-B    GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.79; Apoptosis; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: intracellular membrane-bound organelle; membrane; cytoplasm; immunological synapse; nucleus; cytosol

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: Notch signaling pathway; induction of apoptosis by granzyme; apoptosis; natural killer cell mediated cytotoxicity; cytolysis; protein processing; immune response; proteolysis
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 Research Articles on GZMS-B    1. Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GZMS-B elisa kitPathways associated with GZMS-B elisa kit
 Reference Product  PubMed Publications
 PRF1 elisa kit  >526 publications with GZMS-B and PRF1
 CASP3 elisa kit  >87 publications with GZMS-B and CASP3
 BID elisa kit  >41 publications with GZMS-B and BID
 SERPINB9 elisa kit  >36 publications with GZMS-B and SERPINB9
 CASP7 elisa kit  >13 publications with GZMS-B and CASP7
 IL2RA elisa kit  >9 publications with GZMS-B and IL2RA
 IL2RB elisa kit  >5 publications with GZMS-B and IL2RB
 IL2 elisa kit  >2 publications with GZMS-B and IL2
 Products by Pathway  Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
Diseases associated with GZMS-B elisa kitOrgans/Tissues associated with GZMS-B elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >227 publications with GZMS-B and Neoplasms
 Necrosis Antibodies  >122 publications with GZMS-B and Necrosis
 Inflammation Antibodies  >51 publications with GZMS-B and Inflammation
 Neoplasms, Experimental Antibodies  >35 publications with GZMS-B and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >35 publications with GZMS-B and Disease Models, Animal
 Nervous System Diseases Antibodies  >31 publications with GZMS-B and Nervous System Diseases
 Liver Diseases Antibodies  >29 publications with GZMS-B and Liver Diseases
 Hypersensitivity Antibodies  >24 publications with GZMS-B and Hypersensitivity
 Breast Neoplasms Antibodies  >16 publications with GZMS-B and Breast Neoplasms
 Hepatitis Antibodies  >15 publications with GZMS-B and Hepatitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >838 publications with GZMS-B and Blood
 Kidney Antibodies  >82 publications with GZMS-B and Kidney
 Lung Antibodies  >67 publications with GZMS-B and Lung
 Liver Antibodies  >65 publications with GZMS-B and Liver
 Spleen Antibodies  >63 publications with GZMS-B and Spleen
 Bone Marrow Antibodies  >48 publications with GZMS-B and Bone Marrow
 Heart Antibodies  >35 publications with GZMS-B and Heart
 Intestine Antibodies  >28 publications with GZMS-B and Intestine
 Pancreas Antibodies  >14 publications with GZMS-B and Pancreas
 Stomach Antibodies  >10 publications with GZMS-B and Stomach
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