P17096.3
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,676 Da
NCBI Official Full Name
High mobility group protein HMG-I/HMG-Y
NCBI Official Synonym Full Names
high mobility group AT-hook 1
NCBI Protein Information
high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein R; high mobility group protein A1; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y; high-mobility group (nonhistone chromosomal) protein isoforms I and Y
UniProt Protein Name
High mobility group protein HMG-I/HMG-Y
UniProt Synonym Protein Names
High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R
UniProt Synonym Gene Names
UniProt Entry Name
HMGA1_HUMAN
NCBI Summary for HMGA1
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HMGA1
HMGA1: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. Belongs to the HMGA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: nucleoplasm; transcription factor complex; focal adhesion; cytosol; nucleus
Molecular Function: retinoid X receptor binding; peroxisome proliferator activated receptor binding; protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; AT DNA binding; retinoic acid receptor binding; 5'-deoxyribose-5-phosphate lyase activity; transcription factor binding
Biological Process: DNA unwinding during replication; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; response to virus; DNA catabolic process, endonucleolytic; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; negative regulation of chromatin silencing; nucleosome disassembly; base-excision repair; protein complex assembly; negative regulation of transcription, DNA-dependent
Research Articles on HMGA1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with HMGA1 elisa kit
Pathways associated with HMGA1 elisa kit
Diseases associated with HMGA1 elisa kit
Organs/Tissues associated with HMGA1 elisa kit
|