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IRS-2 elisa kit :: Fish Insulin Receptor Substrate 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS031404 IRS-2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Receptor Substrate 2 (IRS-2), ELISA Kit

 Also Known As   

Fish Insulin Receptor Substrate 2 ELISA Kit

 Product Gene Name   

IRS-2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 13; NC_000013.10 (110406184..110438914, complement). Location: 13q34
 OMIM    600797
 3D Structure    ModBase 3D Structure for Q9Y4H2
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 Species Reactivity    Fish
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    62.5pg/ml-2000pg/ml
 Sensitivity    10pg/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IRS-2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IRS-2 purchase    MBS031404 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Insulin Receptor Substrate 2 (IRS-2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5pg/ml-2000pg/ml in biological research samples containing IRS-2, with an estimated sensitivity of 10pg/ml. The ELISA analytical biochemical technique of the MBS031404 kit is based on IRS-2 antibody-IRS-2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IRS-2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IRS-2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for IRS-2 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of IRS2 (hereafter termed "analyte") in undiluted original Fish body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS031404. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IRS-2. It may not necessarily be applicable to this product.
 NCBI GI #    38683860
 NCBI GeneID    8660
 NCBI Accession #    NP_003740.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003749.2 [Other Products]
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 UniProt Primary Accession #    Q9Y4H2 [Other Products]
 UniProt Secondary Accession #    Q96RR2; Q9BZG0; Q9Y6I5 [Other Products]
 UniProt Related Accession #    Q9Y4H2 [Other Products]
 Molecular Weight    137,334 Da
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 NCBI Official Full Name    insulin receptor substrate 2
 NCBI Official Synonym Full Names    insulin receptor substrate 2
 NCBI Official Symbol    IRS2 [Similar Products]
 NCBI Official Synonym Symbols   
IRS-2
[Similar Products]
 NCBI Protein Information    insulin receptor substrate 2
 UniProt Protein Name    Insulin receptor substrate 2
 Protein Family    Insulin receptor substrate
 UniProt Gene Name    IRS2 [Similar Products]
 UniProt Synonym Gene Names    IRS-2 [Similar Products]
 UniProt Entry Name    IRS2_HUMAN
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 NCBI Summary for IRS-2    This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IRS-2    IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: plasma membrane; cytosol

Molecular Function: protein domain specific binding; signal transducer activity; protein binding; phosphoinositide 3-kinase binding; protein phosphatase binding; protein kinase binding; insulin receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; fibroblast growth factor receptor signaling pathway; regulation of lipid metabolic process; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; lipid homeostasis; glucose metabolic process; signal transduction; positive regulation of fatty acid beta-oxidation; cell proliferation; positive regulation of glucose import; mammary gland development; cellular response to insulin stimulus; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; insulin receptor signaling pathway; response to glucose stimulus; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on IRS-2    1. IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IRS-2 elisa kitPathways associated with IRS-2 elisa kit
 Reference Product  PubMed Publications
 IGF1R elisa kit  >82 publications with IRS-2 and IGF1R
 GRB2 elisa kit  >41 publications with IRS-2 and GRB2
 JAK2 elisa kit  >34 publications with IRS-2 and JAK2
 INSR elisa kit  >17 publications with IRS-2 and INSR
 JAK1 elisa kit  >14 publications with IRS-2 and JAK1
 SOCS1 elisa kit  >5 publications with IRS-2 and SOCS1
 PIK3R1 elisa kit  >5 publications with IRS-2 and PIK3R1
 IL4 elisa kit  >2 publications with IRS-2 and IL4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with IRS-2 elisa kitOrgans/Tissues associated with IRS-2 elisa kit
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >345 publications with IRS-2 and Insulin Resistance
 Neoplasms Antibodies  >136 publications with IRS-2 and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >111 publications with IRS-2 and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >74 publications with IRS-2 and Hyperglycemia
 Liver Diseases Antibodies  >50 publications with IRS-2 and Liver Diseases
 Fatty Liver Antibodies  >41 publications with IRS-2 and Fatty Liver
 Glucose Intolerance Antibodies  >35 publications with IRS-2 and Glucose Intolerance
 Necrosis Antibodies  >34 publications with IRS-2 and Necrosis
 Breast Neoplasms Antibodies  >27 publications with IRS-2 and Breast Neoplasms
 Inflammation Antibodies  >26 publications with IRS-2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >224 publications with IRS-2 and Blood
 Liver Antibodies  >216 publications with IRS-2 and Liver
 Muscle Antibodies  >184 publications with IRS-2 and Muscle
 Pancreas Antibodies  >152 publications with IRS-2 and Pancreas
 Adipose Tissue Antibodies  >85 publications with IRS-2 and Adipose Tissue
 Brain Antibodies  >74 publications with IRS-2 and Brain
 Connective Tissue Antibodies  >70 publications with IRS-2 and Connective Tissue
 Kidney Antibodies  >37 publications with IRS-2 and Kidney
 Heart Antibodies  >33 publications with IRS-2 and Heart
 Ovary Antibodies  >28 publications with IRS-2 and Ovary
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