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LOX-1 elisa kit :: Fish Lctin Like Oxldl Receptor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS012107 LOX-1 elisa kit
Unit / Price
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 Product Name   

Lctin Like Oxldl Receptor 1 (LOX-1), ELISA Kit

 Also Known As   

Fish Lctin Like Oxldl Receptor 1 ELISA Kit

 Product Gene Name   

LOX-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O70156
 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LOX-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LOX-1 purchase    MBS012107 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lctin Like Oxldl Receptor 1 (LOX-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LOX-1. The ELISA analytical biochemical technique of the MBS012107 kit is based on LOX-1 antibody-LOX-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LOX-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LOX-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LOX-1. It may not necessarily be applicable to this product.
 NCBI GI #    4008187
 NCBI GeneID    140914
 NCBI Accession #    BAA35123.1 [Other Products]
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 UniProt Primary Accession #    O70156 [Other Products]
 UniProt Related Accession #    O70156 [Other Products]
 Molecular Weight    41,890 Da
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 NCBI Official Full Name    lectin-like oxidized low-density lipoprotein receptor
 NCBI Official Synonym Full Names    oxidized low density lipoprotein (lectin-like) receptor 1
 NCBI Official Symbol    Olr1 [Similar Products]
 NCBI Official Synonym Symbols   
LOX-1; Oldr1; Oldlr1
[Similar Products]
 NCBI Protein Information    oxidized low-density lipoprotein receptor 1; ox-LDL receptor 1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; oxidised low density lipoprotein (lectin-like) receptor 1
 UniProt Protein Name    Oxidized low-density lipoprotein receptor 1
 UniProt Synonym Protein Names   
Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1
 UniProt Gene Name    Olr1 [Similar Products]
 UniProt Synonym Gene Names    Lox1; Oldlr1; Ox-LDL receptor 1; LOX-1 [Similar Products]
 UniProt Entry Name    OLR1_RAT
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 NCBI Summary for LOX-1    receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]
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 UniProt Comments for LOX-1    Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Ref.2 Ref.4

Subunit structure: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70

By similarity.

Subcellular location: Cell membrane; Lipid-anchor

By similarity. Cell membrane; Single-pass type II membrane protein

By similarity. Membrane raft

By similarity. Secreted

By similarity. Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation

By similarity.

Tissue specificity: Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells. Ref.1

Induction: By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells. Ref.1 Ref.2

Domain: The cytoplasmic region is required for subcellular sorting on the cell surface

By similarity.The C-type lectin domain mediates the recognition and binding of oxLDL

By similarity.The Neck region contains 3 internal repeats that are only found in rodents.

Post-translational modification: N-glycosylated

By similarity.

Sequence similarities: Contains 1 C-type lectin domain.
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 Research Articles on LOX-1    1. results indicate that LOX-1 is essential in microglia for promoting an inflammatory response in the presence of soluble neuronal-injury signals such as extracellular HSP60, thereby linking neuroinflammation and neurotoxicity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LOX-1 elisa kitPathways associated with LOX-1 elisa kit
 Reference Product  PubMed Publications
 Crp elisa kit  >15 publications with LOX-1 and Crp
 Nos3 elisa kit  >14 publications with LOX-1 and Nos3
 Ccl2 elisa kit  >12 publications with LOX-1 and Ccl2
 Apob elisa kit  >6 publications with LOX-1 and Apob
 Ace elisa kit  >5 publications with LOX-1 and Ace
 Vegfa elisa kit  >2 publications with LOX-1 and Vegfa
 Agt elisa kit  >1 publications with LOX-1 and Agt
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
Diseases associated with LOX-1 elisa kitOrgans/Tissues associated with LOX-1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >219 publications with LOX-1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >72 publications with LOX-1 and Heart Diseases
 Inflammation Antibodies  >60 publications with LOX-1 and Inflammation
 Coronary Disease Antibodies  >60 publications with LOX-1 and Coronary Disease
 Necrosis Antibodies  >42 publications with LOX-1 and Necrosis
 Hypertension Antibodies  >39 publications with LOX-1 and Hypertension
 Myocardial Infarction Antibodies  >28 publications with LOX-1 and Myocardial Infarction
 Dyslipidemias Antibodies  >26 publications with LOX-1 and Dyslipidemias
 Hyperlipidemias Antibodies  >23 publications with LOX-1 and Hyperlipidemias
 Hypercholesterolemia Antibodies  >20 publications with LOX-1 and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >17 publications with LOX-1 and Placenta
 Liver Antibodies  >14 publications with LOX-1 and Liver
 Ovary Antibodies  >13 publications with LOX-1 and Ovary
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