NP_112325.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
41,988 Da
NCBI Official Full Name
mevalonate kinase
NCBI Official Synonym Full Names
mevalonate kinase
NCBI Official Synonym Symbols
NCBI Protein Information
mevalonate kinase
UniProt Protein Name
Mevalonate kinase
UniProt Synonym Gene Names
UniProt Entry Name
KIME_RAT
NCBI Summary for MVK
kinase that catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate; involved in the cholesterol biosynthetic pathway [RGD, Feb 2006]
UniProt Comments for MVK
MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Protein type: RNA-binding; Translation; Kinase, other; EC 2.7.1.36; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis
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Pathways associated with MVK elisa kit
Diseases associated with MVK elisa kit
Organs/Tissues associated with MVK elisa kit
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