AAA51840.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,005 Da
NCBI Official Full Name
2,3-bisphosphoglycerate
NCBI Official Synonym Full Names
bisphosphoglycerate mutase
NCBI Official Synonym Symbols
NCBI Protein Information
bisphosphoglycerate mutase
UniProt Protein Name
Bisphosphoglycerate mutase
UniProt Synonym Protein Names
2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase (EC:3.1.3.13, EC:5.4.2.11); 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM
UniProt Synonym Gene Names
UniProt Entry Name
PMGE_HUMAN
NCBI Summary for 2,3-BPG
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
UniProt Comments for 2,3-BPG
BPGM: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD). A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 5.4.2.4; EC 3.1.3.13; Phosphatase (non-protein); Isomerase; EC 5.4.2.11
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: cytosol
Molecular Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity
Biological Process: carbohydrate metabolic process; dephosphorylation; gluconeogenesis; glycolysis; regulation of pentose-phosphate shunt; respiratory gaseous exchange
Disease: Bisphosphoglycerate Mutase Deficiency
Research Articles on 2,3-BPG
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Products associated with 2,3-BPG elisa kit
Pathways associated with 2,3-BPG elisa kit
Diseases associated with 2,3-BPG elisa kit
Organs/Tissues associated with 2,3-BPG elisa kit
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