NP_736606.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,137 Da
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 10 isoform 2
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 10; gankyrin; ankyrin repeat protein; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 10
UniProt Synonym Protein Names
26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)
UniProt Entry Name
PSD10_HUMAN
NCBI Summary for PSMD10
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
UniProt Comments for PSMD10
PSMD10: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: Xq22.3
Cellular Component: proteasome complex; nucleoplasm; intermediate filament cytoskeleton; cytoplasm; proteasome regulatory particle; nucleus; cytosol
Molecular Function: protein binding; transcription factor binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; protein polyubiquitination; viral reproduction; negative regulation of MAPKKK cascade; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; antigen processing and presentation of peptide antigen via MHC class I; cytoplasmic sequestering of NF-kappaB; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of protein ubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; inhibition of NF-kappaB transcription factor; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Research Articles on PSMD10
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Products associated with PSMD10 elisa kit
Pathways associated with PSMD10 elisa kit
Diseases associated with PSMD10 elisa kit
Organs/Tissues associated with PSMD10 elisa kit
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