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COQ2 elisa kit :: Goat 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7221055 COQ2 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit

 Also Known As   

Goat 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) ELISA Kit

 Product Gene Name   

COQ2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    609825
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 Species Reactivity    Goat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COQ2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COQ2 purchase    MBS7221055 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COQ2. The ELISA analytical biochemical technique of the MBS7221055 kit is based on COQ2 antibody-COQ2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COQ2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COQ2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COQ2. It may not necessarily be applicable to this product.
 NCBI GI #    260656052
 NCBI GeneID    27235
 NCBI Accession #    NP_056512.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_015697.7 [Other Products]
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 UniProt Secondary Accession #    O95331; Q1JQ78; Q684R2 [Other Products]
 UniProt Related Accession #    Q96H96 [Other Products]
 Molecular Weight    35,468 Da
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 NCBI Official Full Name    4-hydroxybenzoate polyprenyltransferase, mitochondrial
 NCBI Official Synonym Full Names    coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
 NCBI Official Symbol    COQ2 [Similar Products]
 NCBI Official Synonym Symbols   
MSA1; CL640; COQ10D1
[Similar Products]
 NCBI Protein Information    4-hydroxybenzoate polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; coenzyme Q2 homolog, prenyltransferase; para-hydroxybenzoate-polyprenyltransferase, mitochondrial
 UniProt Protein Name    4-hydroxybenzoate polyprenyltransferase, mitochondrial
 UniProt Synonym Protein Names   
COQ2 homolog; hCOQ2; Para-hydroxybenzoate--polyprenyltransferase; PHB:polyprenyltransferase
 UniProt Gene Name    COQ2 [Similar Products]
 UniProt Synonym Gene Names    CL640; hCOQ2; PHB:polyprenyltransferase [Similar Products]
 UniProt Entry Name    COQ2_HUMAN
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 NCBI Summary for COQ2    This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]
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 UniProt Comments for COQ2    COQ2: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1). An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Transferase; Membrane protein, integral; EC 2.5.1.39; Membrane protein, multi-pass; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function: 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity

Biological Process: ubiquinone biosynthetic process; isoprenoid biosynthetic process; glycerol metabolic process

Disease: Multiple System Atrophy 1, Susceptibility To; Coenzyme Q10 Deficiency, Primary, 1
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 Research Articles on COQ2    1. The recessive COQ2 mutations recently were nominated to be the genetic cause in a subset of familial and sporadic MSA cases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COQ2 elisa kitPathways associated with COQ2 elisa kit
 Reference Product  PubMed Publications
 COQ9 elisa kit  >11 publications with COQ2 and COQ9
 PDSS2 elisa kit  >11 publications with COQ2 and PDSS2
 COQ6 elisa kit  >8 publications with COQ2 and COQ6
 PDSS1 elisa kit  >5 publications with COQ2 and PDSS1
 CABC1 elisa kit  >2 publications with COQ2 and CABC1
 COQ3 elisa kit  >2 publications with COQ2 and COQ3
 COQ5 elisa kit  >2 publications with COQ2 and COQ5
 APTX elisa kit  >1 publications with COQ2 and APTX
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 Ubiquinol Biosynthesis Pathway antibodies  Ubiquinol Biosynthesis Pathway Diagram
 Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway antibodies  Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway Diagram
 Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway antibodies  Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway Diagram
 Ubiquinone Biosynthesis, Eukaryotes, 4-hydroxybenzoate => Ubiquinone Pathway antibodies  Ubiquinone Biosynthesis, Eukaryotes, 4-hydroxybenzoate => Ubiquinone Pathway Diagram
 Ubiquinone Biosynthesis, Eukaryotes, 4-hydroxybenzoate => Ubiquinone Pathway antibodies  Ubiquinone Biosynthesis, Eukaryotes, 4-hydroxybenzoate => Ubiquinone Pathway Diagram
Diseases associated with COQ2 elisa kit
 Disease Name  Pubmed Publications
 Atrophy Antibodies  >17 publications with COQ2 and Atrophy
 Kidney Diseases Antibodies  >6 publications with COQ2 and Kidney Diseases
 Death Antibodies  >5 publications with COQ2 and Death
 Heart Diseases Antibodies  >2 publications with COQ2 and Heart Diseases
 COENZYME Q10 DEFICIENCY, PRIMARY, 1 Antibodies  >2 publications with COQ2 and COENZYME Q10 DEFICIENCY, PRIMARY, 1
 Dyslipidemias Antibodies  >1 publications with COQ2 and Dyslipidemias
 Acute Kidney Injury Antibodies  >1 publications with COQ2 and Acute Kidney Injury
 Proteinuria Antibodies  >1 publications with COQ2 and Proteinuria
 Edema Antibodies  >1 publications with COQ2 and Edema
 Reperfusion Injury Antibodies  >1 publications with COQ2 and Reperfusion Injury
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