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HPD elisa kit :: Goat 4-hydroxyphenylpyruvate dioxygenase (HPD) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7226680 HPD elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-hydroxyphenylpyruvate dioxygenase (HPD), ELISA Kit

 Also Known As   

Goat 4-hydroxyphenylpyruvate dioxygenase (HPD) ELISA Kit

 Product Gene Name   

HPD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    609695
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 Species Reactivity    Goat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HPD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HPD purchase    MBS7226680 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 4-hydroxyphenylpyruvate dioxygenase (HPD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HPD. The ELISA analytical biochemical technique of the MBS7226680 kit is based on HPD antibody-HPD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HPD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HPD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HPD. It may not necessarily be applicable to this product.
 NCBI GI #    3860238
 NCBI GeneID    3242
 NCBI Accession #    AAC73008.1 [Other Products]
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 UniProt Secondary Accession #    Q13234; A8K461; B3KQ63 [Other Products]
 UniProt Related Accession #    P32754 [Other Products]
 Molecular Weight    40,497 Da
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 NCBI Official Full Name    4-hydroxyphenylpyruvate-dioxygenase
 NCBI Official Synonym Full Names    4-hydroxyphenylpyruvate dioxygenase
 NCBI Official Symbol    HPD [Similar Products]
 NCBI Official Synonym Symbols   
PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE
[Similar Products]
 NCBI Protein Information    4-hydroxyphenylpyruvate dioxygenase; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase
 UniProt Protein Name    4-hydroxyphenylpyruvate dioxygenase
 UniProt Synonym Protein Names   
4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase
 UniProt Gene Name    HPD [Similar Products]
 UniProt Synonym Gene Names    PPD; 4HPPD; HPD; HPPDase [Similar Products]
 UniProt Entry Name    HPPD_HUMAN
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 NCBI Summary for HPD    The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for HPD    HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.13.11.27; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytosol

Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Hawkinsinuria; Tyrosinemia, Type Iii
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 Research Articles on HPD    1. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HPD elisa kitPathways associated with HPD elisa kit
 Reference Product  PubMed Publications
 FAH elisa kit  >8 publications with HPD and FAH
 HGD elisa kit  >2 publications with HPD and HGD
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Phenylalanine And Tyrosine Catabolism Pathway antibodies  Phenylalanine And Tyrosine Catabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Tyrosine Degradation, Tyrosine => Homogentisate Pathway antibodies  Tyrosine Degradation, Tyrosine => Homogentisate Pathway Diagram
 Tyrosine Degradation, Tyrosine => Homogentisate Pathway antibodies  Tyrosine Degradation, Tyrosine => Homogentisate Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
Diseases associated with HPD elisa kitOrgans/Tissues associated with HPD elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >200 publications with HPD and Nervous System Diseases
 Brain Diseases Antibodies  >91 publications with HPD and Brain Diseases
 Necrosis Antibodies  >81 publications with HPD and Necrosis
 Lung Diseases Antibodies  >54 publications with HPD and Lung Diseases
 Liver Neoplasms Antibodies  >52 publications with HPD and Liver Neoplasms
 Urinary Bladder Neoplasms Antibodies  >49 publications with HPD and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >41 publications with HPD and Liver Diseases
 Kidney Diseases Antibodies  >37 publications with HPD and Kidney Diseases
 Liver Neoplasms, Experimental Antibodies  >23 publications with HPD and Liver Neoplasms, Experimental
 Edema Antibodies  >16 publications with HPD and Edema
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >224 publications with HPD and Brain
 Liver Antibodies  >121 publications with HPD and Liver
 Kidney Antibodies  >73 publications with HPD and Kidney
 Lung Antibodies  >71 publications with HPD and Lung
 Eye Antibodies  >33 publications with HPD and Eye
 Lymph Antibodies  >20 publications with HPD and Lymph
 Testis Antibodies  >9 publications with HPD and Testis
 Cervix Antibodies  >5 publications with HPD and Cervix
 Mammary Gland Antibodies  >1 publications with HPD and Mammary Gland
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