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AP3B1 elisa kit :: Goat AP-3 complex subunit beta-1 (AP3B1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7221665 AP3B1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AP-3 complex subunit beta-1 (AP3B1), ELISA Kit

 Also Known As   

Goat AP-3 complex subunit beta-1 (AP3B1) ELISA Kit

 Product Gene Name   

AP3B1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    gene 608233
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 Species Reactivity    Goat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of AP3B1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AP3B1 purchase    MBS7221665 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the AP-3 complex subunit beta-1 (AP3B1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AP3B1. The ELISA analytical biochemical technique of the MBS7221665 kit is based on AP3B1 antibody-AP3B1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AP3B1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AP3B1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for AP3B1 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for AP3B1. It may not necessarily be applicable to this product.
 NCBI GI #    254763431
 NCBI GeneID    8546
 NCBI Accession #    O00203.3 [Other Products]
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 UniProt Secondary Accession #    O00580; Q7Z393; Q9HD66; E5RJ68 [Other Products]
 UniProt Related Accession #    O00203 [Other Products]
 Molecular Weight    116,195 Da
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 NCBI Official Full Name    AP-3 complex subunit beta-1
 NCBI Official Synonym Full Names    adaptor-related protein complex 3, beta 1 subunit
 NCBI Official Symbol    AP3B1 [Similar Products]
 NCBI Official Synonym Symbols   
PE; HPS; HPS2; ADTB3; ADTB3A
[Similar Products]
 NCBI Protein Information    AP-3 complex subunit beta-1; beta-3A-adaptin; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; adaptor-related protein complex 3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain
 UniProt Protein Name    AP-3 complex subunit beta-1
 UniProt Synonym Protein Names   
Adaptor protein complex AP-3 subunit beta-1; Adaptor-related protein complex 3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain
 Protein Family    AP-3 complex
 UniProt Gene Name    AP3B1 [Similar Products]
 UniProt Synonym Gene Names    ADTB3A [Similar Products]
 UniProt Entry Name    AP3B1_HUMAN
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 NCBI Summary for AP3B1    This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
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 UniProt Comments for AP3B1    AP3B1: a subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. Mutations in AP3B1 cause defects of various cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes, and are the cause of Hermansky-Pudlak syndrome 2. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: Golgi apparatus; membrane; lysosomal membrane; clathrin coated vesicle membrane

Molecular Function: GTP-dependent protein binding; protein phosphatase binding

Biological Process: intracellular protein transport; protein targeting to lysosome; melanosome organization and biogenesis; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of NK T cell differentiation; anterograde axon cargo transport; blood coagulation

Disease: Hermansky-pudlak Syndrome 2
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 Research Articles on AP3B1    1. Data indicate that RUN and FYVE domain protein Rabip4'(RUFY1) interacts specifically and directly with adaptor protein complex AP-3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AP3B1 elisa kitPathways associated with AP3B1 elisa kit
 Reference Product  PubMed Publications
 HPS3 elisa kit  >4 publications with AP3B1 and HPS3
 AP3D1 elisa kit  >2 publications with AP3B1 and AP3D1
 HPS4 elisa kit  >2 publications with AP3B1 and HPS4
 AP3S1 elisa kit  >1 publications with AP3B1 and AP3S1
 KIF3A elisa kit  >1 publications with AP3B1 and KIF3A
 AP3M1 elisa kit  >1 publications with AP3B1 and AP3M1
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with AP3B1 elisa kitOrgans/Tissues associated with AP3B1 elisa kit
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with AP3B1 and Disease Models, Animal
 Hermansky Pudlak syndrome 2 Antibodies  >3 publications with AP3B1 and Hermansky Pudlak syndrome 2
 Cardiovascular Diseases Antibodies  >2 publications with AP3B1 and Cardiovascular Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with AP3B1 and Uterine Cervical Neoplasms
 Arteriosclerosis Antibodies  >1 publications with AP3B1 and Arteriosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with AP3B1 and Blood
 Lung Antibodies  >6 publications with AP3B1 and Lung
 Eye Antibodies  >4 publications with AP3B1 and Eye
 Nerve Antibodies  >4 publications with AP3B1 and Nerve
 Ear Antibodies  >4 publications with AP3B1 and Ear
 Skin Antibodies  >3 publications with AP3B1 and Skin
 Bone Antibodies  >2 publications with AP3B1 and Bone
 Brain Antibodies  >2 publications with AP3B1 and Brain
 Kidney Antibodies  >1 publications with AP3B1 and Kidney
 Embryonic Tissue Antibodies  >1 publications with AP3B1 and Embryonic Tissue
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