NP_001097.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
activin receptor type-2B
NCBI Official Synonym Full Names
activin A receptor, type IIB
NCBI Protein Information
activin receptor type-2B
UniProt Protein Name
Activin receptor type-2B
UniProt Synonym Protein Names
Activin receptor type IIB; ACTR-IIB
UniProt Synonym Gene Names
UniProt Entry Name
AVR2B_HUMAN
NCBI Summary for ACVR2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for ACVR2B
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.
Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex
Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; metal ion binding; growth factor binding; activin binding; protein serine/threonine/tyrosine kinase activity; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; pancreas development; embryonic foregut morphogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; lymphangiogenesis; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ growth; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development
Disease: Heterotaxy, Visceral, 4, Autosomal
Research Articles on ACVR2B
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Pathways associated with ACVR2B elisa kit
Diseases associated with ACVR2B elisa kit
Organs/Tissues associated with ACVR2B elisa kit
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