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Agrin elisa kit :: Goat Agrin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS736279 Agrin elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Agrin, ELISA Kit

 Also Known As   

Goat Agrin ELISA Kit

 Product Gene Name   

Agrin elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    gene 254300
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 Species Reactivity    Goat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of Agrin elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Agrin purchase    MBS736279 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Agrin, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Agrin. The ELISA analytical biochemical technique of the MBS736279 kit is based on Agrin antibody-Agrin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Agrin antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Agrin. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for Agrin elisa kit    Neurobiology
NCBI/Uniprot data below describe general gene information for Agrin. It may not necessarily be applicable to this product.
 NCBI GI #    255738
 NCBI GeneID    375790
 NCBI Accession #    AAB23327.1 [Other Products]
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 UniProt Secondary Accession #    Q5SVA1; Q5SVA2; Q60FE1; Q7KYS8; Q8N4J5; Q96IC1; Q9BTD4 [Other Products]
 UniProt Related Accession #    O00468 [Other Products]
 Molecular Weight    216,733 Da
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 NCBI Official Full Name    agrin, partial
 NCBI Official Synonym Full Names    agrin
 NCBI Official Symbol    AGRN [Similar Products]
 NCBI Official Synonym Symbols   
CMSPPD
[Similar Products]
 NCBI Protein Information    agrin; agrin proteoglycan
 UniProt Protein Name    Agrin
 Protein Family    Agrin
 UniProt Gene Name    AGRN [Similar Products]
 UniProt Synonym Gene Names    AGRIN; C90; C22 [Similar Products]
 UniProt Entry Name    AGRIN_HUMAN
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 NCBI Summary for Agrin    This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. [provided by RefSeq, Aug 2011]
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 UniProt Comments for Agrin    AGRN: Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Ligand of the MUSK signaling complex that directly binds LRP4 in this complex and induces the phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Defects in AGRN are a cause of myasthenia, limb-girdle, familial (LGM). A congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.

Protein type: Secreted; Cell adhesion; Extracellular matrix; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; cell surface; Golgi lumen; cytoplasm; plasma membrane; extracellular region; integral to membrane; basal lamina; synapse; cell junction

Molecular Function: heparan sulfate proteoglycan binding; protein binding; structural constituent of cytoskeleton; acetylcholine receptor regulator activity; laminin binding; calcium ion binding; sialic acid binding

Biological Process: positive regulation of filopodium formation; clustering of voltage-gated sodium channels; axon guidance; phototransduction, visible light; extracellular matrix organization and biogenesis; acetylcholine receptor signaling, muscarinic pathway; glycosaminoglycan metabolic process; neurotransmitter receptor metabolic process; pathogenesis; positive regulation of synaptic growth at neuromuscular junction; signal transduction; receptor clustering; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; plasma membrane organization and biogenesis; positive regulation of neuron apoptosis; carbohydrate metabolic process; synapse organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of receptor activity; retinoid metabolic process; neuromuscular junction development

Disease: Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects
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 Research Articles on Agrin    1. study identifies a spontaneous agrin mutation that reduces the ability of z+ agrin to activate MuSK and induce AChR clustering; this results in a severe congenital myasthenic syndrome in the patient, with both pre- and postsynaptic defects at the neuromuscular junction
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Agrin elisa kitPathways associated with Agrin elisa kit
 Reference Product  PubMed Publications
 ATP1A3 elisa kit  >1 publications with Agrin and ATP1A3
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with Agrin elisa kitOrgans/Tissues associated with Agrin elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with Agrin and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with Agrin and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with Agrin and Congenital Abnormalities
 Disease Models, Animal Antibodies  >1 publications with Agrin and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with Agrin and Cell Transformation, Neoplastic
 Death Antibodies  >1 publications with Agrin and Death
 Kidney Diseases Antibodies  >1 publications with Agrin and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with Agrin and Brain
 Nerve Antibodies  >4 publications with Agrin and Nerve
 Embryonic Tissue Antibodies  >4 publications with Agrin and Embryonic Tissue
 Uterus Antibodies  >2 publications with Agrin and Uterus
 Cervix Antibodies  >1 publications with Agrin and Cervix
 Heart Antibodies  >1 publications with Agrin and Heart
 Bone Antibodies  >1 publications with Agrin and Bone
 Liver Antibodies  >1 publications with Agrin and Liver
 Kidney Antibodies  >1 publications with Agrin and Kidney
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