AAD30390.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,849 Da
NCBI Official Full Name
alternative macrophage activation-associated CC-chemokine
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
NCBI Official Synonym Symbols
CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18 [Similar Products]
NCBI Protein Information
C-C motif chemokine 18; CC chemokine PARC; CC chemokine ligand 18; chemokine (C-C), dendritic; dendritic cell chemokine 1; small inducible cytokine A18; small-inducible cytokine A18; macrophage inflammatory protein 4; pulmonary and activation-regulated chemokine; alternative macrophage activation-associated CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
UniProt Protein Name
C-C motif chemokine 18
UniProt Synonym Protein Names
Alternative macrophage activation-associated CC chemokine 1; AMAC-1; CC chemokine PARC; Dendritic cell chemokine 1; DC-CK1; Macrophage inflammatory protein 4; MIP-4; Pulmonary and activation-regulated chemokine; Small-inducible cytokine A18Cleaved into the following 3 chains:CCL18(1-68); CCL18(3-69); CCL18(4-69)
UniProt Synonym Gene Names
UniProt Entry Name
CCL18_HUMAN
NCBI Summary for AMAC-1
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
UniProt Comments for AMAC-1
CCL18: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space
Molecular Function: protein binding; chemokine activity
Biological Process: cell-cell signaling; response to biotic stimulus; immune response; cell communication; chemotaxis; inflammatory response; signal transduction
Research Articles on AMAC-1
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Products associated with AMAC-1 elisa kit
Pathways associated with AMAC-1 elisa kit
Diseases associated with AMAC-1 elisa kit
Organs/Tissues associated with AMAC-1 elisa kit
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