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AGT elisa kit :: Goat Angiotensinogen ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005217 AGT elisa kit
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 Product Name   

Angiotensinogen (AGT), ELISA Kit

★Popular Item★
 Also Known As   

Goat Angiotensinogen ELISA Kit

 Product Gene Name   

AGT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (230838269..230850336, complement). Location: 1q42.2
 OMIM    106150
 3D Structure    ModBase 3D Structure for P01019
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 Species Reactivity    Goat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AGT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AGT purchase    MBS005217 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Angiotensinogen (AGT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AGT. The ELISA analytical biochemical technique of the MBS005217 kit is based on AGT antibody-AGT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AGT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AGT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AGT. It may not necessarily be applicable to this product.
 NCBI GI #    532198
 NCBI GeneID    183
 NCBI Accession #    AAA51679.1 [Other Products]
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 UniProt Primary Accession #    P01019 [Other Products]
 UniProt Secondary Accession #    Q16358; Q16359; Q96F91 [Other Products]
 UniProt Related Accession #    P01019 [Other Products]
 Molecular Weight    53,154 Da
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 NCBI Official Full Name    angiotensinogen
 NCBI Official Synonym Full Names    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
 NCBI Official Symbol    AGT [Similar Products]
 NCBI Official Synonym Symbols   
ANHU; SERPINA8
[Similar Products]
 NCBI Protein Information    angiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor
 UniProt Protein Name    Angiotensinogen
 UniProt Synonym Protein Names   
Serpin A8Cleaved into the following 8 chains:Angiotensin-1; Alternative name(s):; Angiotensin 1-10; Angiotensin I; Ang IAngiotensin-2; Alternative name(s):; Angiotensin 1-8; Angiotensin II; Ang IIAngiotensin-3; Alternative name(s):; Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin IIAngiotensin-4; Alternative name(s):; Angiotensin 3-8; Angiotensin IV
 Protein Family    Angiotensinogen
 UniProt Gene Name    AGT [Similar Products]
 UniProt Synonym Gene Names    SERPINA8; Ang I; Ang II; Ang III; Ang IV [Similar Products]
 UniProt Entry Name    ANGT_HUMAN
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 NCBI Summary for AGT    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGT    angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; sodium channel regulator activity; growth factor activity; hormone activity; superoxide-generating NADPH oxidase activator activity; type 2 angiotensin receptor binding; type 1 angiotensin receptor binding

Biological Process: renal system process; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; establishment of blood-nerve barrier; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; female pregnancy; positive regulation of multicellular organism growth; positive regulation of vasodilation; activation of NF-kappaB transcription factor; ovarian follicle rupture; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of superoxide release; negative regulation of neuron apoptosis; kidney development; positive regulation of NAD(P)H oxidase activity; positive regulation of cytokine production; angiotensin mediated regulation of renal output; regulation of calcium ion transport; response to muscle activity involved in regulation of muscle adaptation; regulation of norepinephrine secretion; negative regulation of tissue remodeling; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure; phospholipase C activation; regulation of transmission of nerve impulse; regulation of vasoconstriction; smooth muscle cell differentiation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); nitric oxide mediated signal transduction; cytokine secretion; regulation of long-term neuronal synaptic plasticity; peristalsis; cell-matrix adhesion; renin-angiotensin regulation of aldosterone production; positive regulation of cellular protein metabolic process; smooth muscle cell proliferation; cellular lipid metabolic process; angiotensin maturation; excretion; vasodilation; response to salt stress; negative regulation of cell proliferation; fibroblast proliferation; positive regulation of MAPKKK cascade; renin-angiotensin regulation of blood vessel size; positive regulation of epidermal growth factor receptor signaling pathway; regulation of blood pressure; renin-angiotensin regulation of blood volume; regulation of cell growth; angiotensin mediated drinking behavior; artery smooth muscle contraction; aging; positive regulation of fatty acid biosynthetic process; blood vessel development; cellular sodium ion homeostasis; renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure; activation of NF-kappaB-inducing kinase; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; ureteric bud branching; G-protein signaling, coupled to cGMP nucleotide second messenger; blood vessel remodeling; negative regulation of cell growth; response to cold; astrocyte activation; positive regulation of inflammatory response

Disease: Renal Tubular Dysgenesis; Hypertension, Essential
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 Research Articles on AGT    1. in healthy, low-risk subjects with family history of coronary artery disease, AGT M235T variant was most significant predictor of coronary artery calcification independent of blood pressure, raising the possibility of an alternative biological pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGT elisa kitPathways associated with AGT elisa kit
 Reference Product  PubMed Publications
 ACE elisa kit  >419 publications with AGT and ACE
 AGTR1 elisa kit  >94 publications with AGT and AGTR1
 REN elisa kit  >53 publications with AGT and REN
 AGTR2 elisa kit  >51 publications with AGT and AGTR2
 ACE2 elisa kit  >26 publications with AGT and ACE2
 TGFB1 elisa kit  >22 publications with AGT and TGFB1
 IL6 elisa kit  >5 publications with AGT and IL6
 INS elisa kit  >4 publications with AGT and INS
 KNG1 elisa kit  >1 publications with AGT and KNG1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with AGT elisa kitOrgans/Tissues associated with AGT elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >543 publications with AGT and Cardiovascular Diseases
 Hypertension Antibodies  >512 publications with AGT and Hypertension
 Kidney Diseases Antibodies  >249 publications with AGT and Kidney Diseases
 Heart Diseases Antibodies  >166 publications with AGT and Heart Diseases
 Hypertension, Renal Antibodies  >115 publications with AGT and Hypertension, Renal
 Myocardial Ischemia Antibodies  >98 publications with AGT and Myocardial Ischemia
 Hypertrophy Antibodies  >75 publications with AGT and Hypertrophy
 Atherosclerosis Antibodies  >67 publications with AGT and Atherosclerosis
 Myocardial Infarction Antibodies  >59 publications with AGT and Myocardial Infarction
 Proteinuria Antibodies  >58 publications with AGT and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >666 publications with AGT and Blood
 Kidney Antibodies  >283 publications with AGT and Kidney
 Liver Antibodies  >277 publications with AGT and Liver
 Heart Antibodies  >151 publications with AGT and Heart
 Brain Antibodies  >116 publications with AGT and Brain
 Lung Antibodies  >70 publications with AGT and Lung
 Muscle Antibodies  >66 publications with AGT and Muscle
 Bone Antibodies  >61 publications with AGT and Bone
 Connective Tissue Antibodies  >50 publications with AGT and Connective Tissue
 Ovary Antibodies  >38 publications with AGT and Ovary
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