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ABCA1 elisa kit :: Goat Atp Binding Cassette Transporter A1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS010540 ABCA1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Atp Binding Cassette Transporter A1 (ABCA1), ELISA Kit

 Also Known As   

Goat Atp Binding Cassette Transporter A1 ELISA Kit

 Product Gene Name   

ABCA1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 9; NC_000009.11 (107543283..107690527, complement). Location: 9q31.1
 OMIM    205400
 3D Structure    ModBase 3D Structure for O95477
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 Species Reactivity    Goat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ABCA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ABCA1 purchase    MBS010540 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Atp Binding Cassette Transporter A1 (ABCA1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABCA1. The ELISA analytical biochemical technique of the MBS010540 kit is based on ABCA1 antibody-ABCA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABCA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABCA1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
 NCBI GI #    21536376
 NCBI GeneID    19
 NCBI Accession #    NP_005493.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005502.3 [Other Products]
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 UniProt Primary Accession #    O95477 [Other Products]
 UniProt Secondary Accession #    Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09 [Other Products]
 UniProt Related Accession #    O95477 [Other Products]
 Molecular Weight    254,302 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family A member 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family A (ABC1), member 1
 NCBI Official Symbol    ABCA1 [Similar Products]
 NCBI Official Synonym Symbols   
TGD; ABC1; CERP; ABC-1; HDLDT1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 1; membrane-bound; ATP-binding cassette transporter A1; cholesterol efflux regulatory protein
 UniProt Protein Name    ATP-binding cassette sub-family A member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
 Protein Family    ABC transporter A family
 UniProt Gene Name    ABCA1 [Similar Products]
 UniProt Synonym Gene Names    ABC1; CERP; ABC-1 [Similar Products]
 UniProt Entry Name    ABCA1_HUMAN
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 NCBI Summary for ABCA1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA1    ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass; Vesicle

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: Golgi apparatus; integral to plasma membrane; endocytic vesicle; perinuclear region of cytoplasm; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; small GTPase binding; apolipoprotein A-I binding; protein binding; phospholipid transporter activity; syntaxin binding; cholesterol transporter activity; anion transmembrane transporter activity; phospholipid binding; ATP binding; receptor binding

Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; intracellular cholesterol transport; cholesterol efflux; lipoprotein metabolic process; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; platelet dense granule organization and biogenesis; phospholipid efflux; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; peptide secretion; phospholipid homeostasis

Disease: Tangier Disease; Hypoalphalipoproteinemia, Primary; Hypercholesterolemia, Familial
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 Research Articles on ABCA1    1. Results show that Carriers of loss of function ABCA1 mutations display a larger atherosclerotic burden compared with age and sex-matched controls, implying a higher risk for CVD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCA1 elisa kitDiseases associated with ABCA1 elisa kit
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >604 publications with ABCA1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >444 publications with ABCA1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >226 publications with ABCA1 and Dyslipidemias
 Tangier Disease Antibodies  >195 publications with ABCA1 and Tangier Disease
 Inflammation Antibodies  >159 publications with ABCA1 and Inflammation
 Coronary Disease Antibodies  >153 publications with ABCA1 and Coronary Disease
 Familial HDL deficiency Antibodies  >139 publications with ABCA1 and Familial HDL deficiency
 Hypoalphalipoproteinemias Antibodies  >122 publications with ABCA1 and Hypoalphalipoproteinemias
 Heart Diseases Antibodies  >119 publications with ABCA1 and Heart Diseases
 Peripheral Nervous System Diseases Antibodies  >115 publications with ABCA1 and Peripheral Nervous System Diseases
Organs/Tissues associated with ABCA1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >690 publications with ABCA1 and Liver
 Blood Antibodies  >601 publications with ABCA1 and Blood
 Vascular Antibodies  >231 publications with ABCA1 and Vascular
 Brain Antibodies  >140 publications with ABCA1 and Brain
 Intestine Antibodies  >93 publications with ABCA1 and Intestine
 Kidney Antibodies  >76 publications with ABCA1 and Kidney
 Lung Antibodies  >63 publications with ABCA1 and Lung
 Muscle Antibodies  >63 publications with ABCA1 and Muscle
 Bone Antibodies  >55 publications with ABCA1 and Bone
 Bone Marrow Antibodies  >52 publications with ABCA1 and Bone Marrow
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