NP_004646.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,558 Da
NCBI Official Full Name
axin-2
NCBI Official Synonym Full Names
axin 2
NCBI Official Synonym Symbols
NCBI Protein Information
axin-2; conductin; axin-like protein; axis inhibition protein 2
UniProt Protein Name
Axin-2
UniProt Synonym Protein Names
Axin-like protein; Axil; Axis inhibition protein 2; Conductin
UniProt Synonym Gene Names
UniProt Entry Name
AXIN2_HUMAN
NCBI Summary for AXIN2
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
UniProt Comments for AXIN2
axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q24.1
Cellular Component: nucleoplasm; microtubule cytoskeleton; Golgi apparatus; centrosome; cytoplasmic microtubule; postsynaptic density; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; cell cortex; nucleus; beta-catenin destruction complex; cytosol
Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity
Biological Process: odontogenesis; cell proliferation; negative regulation of cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; negative regulation of osteoblast differentiation; dorsal/ventral axis specification; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity
Disease: Oligodontia-colorectal Cancer Syndrome
Research Articles on AXIN2
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Products associated with AXIN2 elisa kit
Pathways associated with AXIN2 elisa kit
Diseases associated with AXIN2 elisa kit
Organs/Tissues associated with AXIN2 elisa kit
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