NP_066960.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,204 Da
NCBI Official Full Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
NCBI Official Synonym Full Names
tumor necrosis factor, alpha-induced protein 1 (endothelial)
NCBI Official Synonym Symbols
B12; B61; EDP1; BTBD34; hBACURD2 [Similar Products]
NCBI Protein Information
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1
UniProt Protein Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
UniProt Synonym Protein Names
BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial
UniProt Synonym Gene Names
UniProt Entry Name
BACD2_HUMAN
NCBI Summary for TNFAIP1
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFAIP1
TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family.
Protein type: DNA replication; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q22-q23
Cellular Component: cytoplasm; nucleolus; endosome
Molecular Function: protein domain specific binding; protein binding; ubiquitin-protein ligase activity; GTP-Rho binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cell migration; embryonic development; negative regulation of Rho protein signal transduction; apoptosis; stress fiber formation; protein ubiquitination; immune response; DNA replication; protein homooligomerization; positive regulation of DNA replication
Research Articles on TNFAIP1
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Diseases associated with TNFAIP1 elisa kit
Organs/Tissues associated with TNFAIP1 elisa kit
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