NP_001230174.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,206 Da
NCBI Official Full Name
bone marrow proteoglycan isoform 2 preproprotein
NCBI Official Synonym Full Names
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
NCBI Protein Information
bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein
UniProt Protein Name
Bone marrow proteoglycan
UniProt Synonym Protein Names
Proteoglycan 2Cleaved into the following chain:Eosinophil granule major basic protein; EMBP; MBPAlternative name(s):Pregnancy-associated major basic protein
UniProt Synonym Gene Names
UniProt Entry Name
PRG2_HUMAN
NCBI Summary for PRG2
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for PRG2
PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Protein type: Secreted, signal peptide; Secreted; Vesicle
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: transport vesicle; extracellular region
Molecular Function: heparin binding; carbohydrate binding
Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode
Research Articles on PRG2
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Products associated with PRG2 elisa kit
Pathways associated with PRG2 elisa kit
Diseases associated with PRG2 elisa kit
Organs/Tissues associated with PRG2 elisa kit
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