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MNAT1 elisa kit :: Goat CDK-activating kinase assembly factor MAT1 (MNAT1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7206108 MNAT1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK-activating kinase assembly factor MAT1 (MNAT1), ELISA Kit

 Also Known As   

Goat CDK-activating kinase assembly factor MAT1 (MNAT1) ELISA Kit

 Product Gene Name   

MNAT1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    602659
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 Species Reactivity    Goat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact technical support.
 Other Notes    Small volumes of MNAT1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MNAT1 purchase    MBS7206108 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CDK-activating kinase assembly factor MAT1 (MNAT1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards render a theoretical kit detection range in biological research samples containing MNAT1. The ELISA analytical biochemical technique of the MBS7206108 kit is based on MNAT1 antibody-MNAT1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MNAT1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MNAT1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for MNAT1 elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for MNAT1. It may not necessarily be applicable to this product.
 NCBI GI #    295789085
 NCBI GeneID    4331
 NCBI Accession #    NP_001171434.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177963.1 [Other Products]
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 UniProt Secondary Accession #    Q15817; Q6ICQ7; G3V1U8 [Other Products]
 UniProt Related Accession #    P51948 [Other Products]
 Molecular Weight    31,148 Da
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 NCBI Official Full Name    CDK-activating kinase assembly factor MAT1 isoform 2
 NCBI Official Synonym Full Names    MNAT CDK-activating kinase assembly factor 1
 NCBI Official Symbol    MNAT1 [Similar Products]
 NCBI Official Synonym Symbols   
MAT1; TFB3; CAP35; RNF66
[Similar Products]
 NCBI Protein Information    CDK-activating kinase assembly factor MAT1; RING finger protein 66; RING finger protein MAT1; CDK7/cyclin-H assembly factor; cyclin G1 interacting protein; cyclin-G1-interacting protein; menage a trois 1 (CAK assembly factor); menage a trois homolog 1, cyclin H assembly factor
 UniProt Protein Name    CDK-activating kinase assembly factor MAT1
 UniProt Synonym Protein Names   
CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36
 Protein Family    CDK-activating kinase assembly factor
 UniProt Gene Name    MNAT1 [Similar Products]
 UniProt Synonym Gene Names    CAP35; MAT1; RNF66 [Similar Products]
 UniProt Entry Name    MAT1_HUMAN
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 NCBI Summary for MNAT1    The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for MNAT1    MNAT1: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 14q23

Cellular Component: nucleoplasm; holo TFIIH complex; cytoplasm

Molecular Function: RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; zinc ion binding; protein N-terminus binding

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; positive regulation of smooth muscle cell proliferation; protein amino acid phosphorylation; regulation of gene expression, epigenetic; mRNA capping; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; protein complex assembly; nucleotide-excision repair, DNA damage removal; G2/M transition of mitotic cell cycle; adult heart development; transcription initiation from RNA polymerase II promoter; ventricular system development; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; regulation of transcription from RNA polymerase II promoter; cell proliferation; nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; transcription initiation from RNA polymerase I promoter; response to calcium ion; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
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 Research Articles on MNAT1    1. The intrinsically programmed MAT1 expression and fragmentation regulate granulopoiesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MNAT1 elisa kitPathways associated with MNAT1 elisa kit
 Reference Product  PubMed Publications
 CDK7 elisa kit  >9 publications with MNAT1 and CDK7
 CCNH elisa kit  >7 publications with MNAT1 and CCNH
 ERCC2 elisa kit  >1 publications with MNAT1 and ERCC2
 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cyclin A/B1 Associated Events During G2/M Transition Pathway antibodies  Cyclin A/B1 Associated Events During G2/M Transition Pathway Diagram
 Cyclin A:Cdk2-associated Events At S Phase Entry Pathway antibodies  Cyclin A:Cdk2-associated Events At S Phase Entry Pathway Diagram
 Cyclin D Associated Events In G1 Pathway antibodies  Cyclin D Associated Events In G1 Pathway Diagram
 Cyclin E Associated Events During G1/S Transition Pathway antibodies  Cyclin E Associated Events During G1/S Transition Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Organs/Tissues associated with MNAT1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with MNAT1 and Blood
 Brain Antibodies  >3 publications with MNAT1 and Brain
 Connective Tissue Antibodies  >2 publications with MNAT1 and Connective Tissue
 Embryonic Tissue Antibodies  >2 publications with MNAT1 and Embryonic Tissue
 Thyroid Antibodies  >1 publications with MNAT1 and Thyroid
 Heart Antibodies  >1 publications with MNAT1 and Heart
 Placenta Antibodies  >1 publications with MNAT1 and Placenta
 Testis Antibodies  >1 publications with MNAT1 and Testis
 Eye Antibodies  >1 publications with MNAT1 and Eye
 Lung Antibodies  >1 publications with MNAT1 and Lung
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