EAX01241.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,809 Da
NCBI Official Full Name
cadherin 2, type 1, N-cadherin (neuronal), isoform CRA_b
NCBI Official Synonym Full Names
cadherin 2, type 1, N-cadherin (neuronal)
NCBI Protein Information
cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325
UniProt Synonym Gene Names
UniProt Entry Name
CADH2_HUMAN
NCBI Summary for CDHN
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
UniProt Comments for CDHN
CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: focal adhesion; cell-cell adherens junction; lamellipodium; apical plasma membrane; plasma membrane; integral to membrane; synapse; intercellular junction; catenin complex; fascia adherens
Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; alpha-catenin binding
Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; cell migration; muscle cell differentiation; glial cell differentiation; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; positive regulation of muscle cell differentiation; striated muscle cell differentiation; blood vessel morphogenesis; homophilic cell adhesion; cell adhesion
Research Articles on CDHN
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Products associated with CDHN elisa kit
Pathways associated with CDHN elisa kit
Diseases associated with CDHN elisa kit
Organs/Tissues associated with CDHN elisa kit
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