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CILP elisa kit :: Goat Cartilage intermediate layer protein 1 (CILP) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7220284 CILP elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cartilage intermediate layer protein 1 (CILP), ELISA Kit

 Also Known As   

Goat Cartilage intermediate layer protein 1 (CILP) ELISA Kit

 Product Gene Name   

CILP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 603932
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 Species Reactivity    Goat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CILP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CILP purchase    MBS7220284 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cartilage intermediate layer protein 1 (CILP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CILP. The ELISA analytical biochemical technique of the MBS7220284 kit is based on CILP antibody-CILP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CILP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CILP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CILP elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for CILP. It may not necessarily be applicable to this product.
 NCBI GI #    317373560
 NCBI GeneID    8483
 NCBI Accession #    O75339.4 [Other Products]
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 UniProt Secondary Accession #    Q6UW99; Q8IYI5; B2R8F7 [Other Products]
 UniProt Related Accession #    O75339 [Other Products]
 Molecular Weight    132,565 Da
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 NCBI Official Full Name    Cartilage intermediate layer protein 1
 NCBI Official Synonym Full Names    cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
 NCBI Official Symbol    CILP [Similar Products]
 NCBI Official Synonym Symbols   
CILP-1; HsT18872
[Similar Products]
 NCBI Protein Information    cartilage intermediate layer protein 1; cartilage intermediate-layer protein; cartilage intermediate layer protein 1 C1; cartilage intermediate layer protein 1 C2
 UniProt Protein Name    Cartilage intermediate layer protein 1
 UniProt Synonym Protein Names   
Cartilage intermediate-layer proteinCleaved into the following 2 chains:Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2
 Protein Family    Cartilage intermediate layer protein
 UniProt Gene Name    CILP [Similar Products]
 UniProt Synonym Gene Names    UNQ602/PRO1188; CILP-1 [Similar Products]
 UniProt Entry Name    CILP1_HUMAN
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 NCBI Summary for CILP    Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
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 UniProt Comments for CILP    CILP: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Defects in CILP are a cause of susceptibility to intervertebral disk disease (IDD). A common musculo- skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr (PubMed:15864306).

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix

Molecular Function: nucleotide diphosphatase activity; alkaline phosphatase activity

Biological Process: negative regulation of insulin-like growth factor receptor signaling pathway

Disease: Intervertebral Disc Disease
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 Research Articles on CILP    1. CILP is involved in the etiology of intervertebral disc degeneration among young adults.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CILP elisa kitDiseases associated with CILP elisa kit
 Reference Product  PubMed Publications
 BMP2 elisa kit  >2 publications with CILP and BMP2
 FURIN elisa kit  >1 publications with CILP and FURIN
 COL9A2 elisa kit  >1 publications with CILP and COL9A2
 COL9A3 elisa kit  >1 publications with CILP and COL9A3
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with CILP and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >2 publications with CILP and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with CILP and Inflammation
 Genital Diseases, Female Antibodies  >1 publications with CILP and Genital Diseases, Female
 Intervertebral disc disease Antibodies  >1 publications with CILP and Intervertebral disc disease
Organs/Tissues associated with CILP elisa kit
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >7 publications with CILP and Connective Tissue
 Muscle Antibodies  >1 publications with CILP and Muscle
 Trachea Antibodies  >1 publications with CILP and Trachea
 Brain Antibodies  >1 publications with CILP and Brain
 Heart Antibodies  >1 publications with CILP and Heart
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