NP_001976.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,844 Da
NCBI Official Full Name
electron transfer flavoprotein subunit beta isoform 1
NCBI Official Synonym Full Names
electron-transfer-flavoprotein, beta polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
electron transfer flavoprotein subunit beta; beta-ETF; electron transfer flavoprotein beta subunit; electron transfer flavoprotein beta-subunit; electron transfer flavoprotein, beta polypeptide; electron-transferring-flavoprotein, beta polypeptide
UniProt Protein Name
Electron transfer flavoprotein subunit beta
UniProt Synonym Gene Names
UniProt Entry Name
ETFB_HUMAN
NCBI Summary for ETFbeta
This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ETFbeta
ETFB: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B). GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF beta-subunit/FixA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: mitochondrion; intracellular membrane-bound organelle; mitochondrial matrix
Molecular Function: electron carrier activity
Biological Process: cellular metabolic process
Disease: Multiple Acyl-coa Dehydrogenase Deficiency
Research Articles on ETFbeta
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Products associated with ETFbeta elisa kit
Pathways associated with ETFbeta elisa kit
Diseases associated with ETFbeta elisa kit
Organs/Tissues associated with ETFbeta elisa kit
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