AAS83395.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,746 Da
NCBI Official Full Name
epidermal growth factor, partial
NCBI Official Synonym Full Names
epidermal growth factor
NCBI Official Synonym Symbols
NCBI Protein Information
pro-epidermal growth factor; beta-urogastrone
UniProt Protein Name
Pro-epidermal growth factor
UniProt Synonym Protein Names
Urogastrone
UniProt Synonym Gene Names
UniProt Entry Name
EGF_HUMAN
NCBI Summary for EGF
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for EGF
EGF: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral; Hormone
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: extracellular space; lysosomal membrane; integral to membrane; plasma membrane; extracellular region
Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activator activity; growth factor activity; calcium ion binding; epidermal growth factor receptor binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activation (dimerization); nerve growth factor receptor signaling pathway; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; signal transduction; positive regulation of MAP kinase activity; platelet degranulation; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; angiogenesis; DNA replication; positive regulation of granule cell precursor proliferation; positive regulation of DNA binding; STAT protein nuclear translocation; epidermal growth factor receptor signaling pathway; platelet activation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; branching morphogenesis of a tube; innate immune response; negative regulation of secretion; blood coagulation; positive regulation of phosphorylation
Disease: Hypomagnesemia 4, Renal
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Products associated with EGF elisa kit
Pathways associated with EGF elisa kit
Diseases associated with EGF elisa kit
Organs/Tissues associated with EGF elisa kit
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