CAA39935.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,784 Da
NCBI Official Full Name
fibrillarin
NCBI Official Synonym Full Names
fibrillarin
NCBI Protein Information
rRNA 2'-O-methyltransferase fibrillarin; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1
UniProt Protein Name
rRNA 2'-O-methyltransferase fibrillarin
UniProt Synonym Protein Names
34 kDa nucleolar scleroderma antigen
UniProt Synonym Gene Names
UniProt Entry Name
FBRL_HUMAN
NCBI Summary for FB
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
UniProt Comments for FB
FBL: Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Interacts with NOLC1. Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain NHP2L1, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Y small nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20. Interacts with DDX5. Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein type: Methyltransferase; EC 2.1.1.-; RNA processing; RNA-binding; Nucleolus
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: Cajal body; granular component; membrane; nucleolus; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: osteoblast differentiation; snoRNA metabolic process; tRNA processing; rRNA processing
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Pathways associated with FB elisa kit
Diseases associated with FB elisa kit
Organs/Tissues associated with FB elisa kit
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