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FLNB elisa kit :: Goat Filamin B, Beta ELISA Kit

Scan QR to view Datasheet Catalog #    MBS743401
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Filamin B, Beta (FLNB), ELISA Kit

 Also Known As   

Goat Filamin B, Beta ELISA Kit

 Product Gene Name   

FLNB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603381
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 Species Reactivity    Goat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Sensitivity    0.1 ng/mL.
 Intended Uses    This FLNB ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Goat FLNB. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FLNB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FLNB purchase    MBS743401 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin B, Beta (FLNB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLNB, with an estimated sensitivity of 0.1 ng/mL. The ELISA analytical biochemical technique of the MBS743401 kit is based on FLNB antibody-FLNB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLNB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLNB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FLNB elisa kit

   Principle of the Assay: FLNB ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-FLNB antibody and an FLNB-HRP conjugate. The assay sample and buffer are incubated together with FLNB-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the FLNB concentration since FLNB from samples and FLNB-HRP conjugate compete for the anti-FLNB antibody binding site. Since the number of sites is limited, as more sites are occupied by FLNB from the sample, fewer sites are left to bind FLNB-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The FLNB concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for FLNB elisa kit    Signal Transduction
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 Typical Testing Data/Standard Curve (for reference only) of FLNB elisa kit    FLNB elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS743401. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.
 NCBI GI #    256222415
 NCBI GeneID    2317
 NCBI Accession #    NP_001157791.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001164319.1 [Other Products]
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 UniProt Secondary Accession #    Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4 [Other Products]
 UniProt Related Accession #    O75369 [Other Products]
 Molecular Weight    276,939 Da
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 NCBI Official Full Name    filamin-B isoform 4
 NCBI Official Synonym Full Names    filamin B, beta
 NCBI Official Symbol    FLNB [Similar Products]
 NCBI Official Synonym Symbols   
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
[Similar Products]
 NCBI Protein Information    filamin-B; filamin-3; beta-filamin; ABP-280 homolog; filamin homolog 1; thyroid autoantigen; actin binding protein 278; actin-binding-like protein; Larsen syndrome 1 (autosomal dominant)
 UniProt Protein Name    Filamin-B
 UniProt Synonym Protein Names   
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
 Protein Family    Filamin
 UniProt Gene Name    FLNB [Similar Products]
 UniProt Synonym Gene Names    FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP [Similar Products]
 UniProt Entry Name    FLNB_HUMAN
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 NCBI Summary for FLNB    This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
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 UniProt Comments for FLNB    FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: focal adhesion; cytoplasm; stress fiber; plasma membrane; integral to membrane; cell cortex; cytosol; Z disc; actin cytoskeleton

Molecular Function: identical protein binding; protein binding; actin binding

Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; signal transduction; cell differentiation; actin cytoskeleton organization and biogenesis

Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii
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 Research Articles on FLNB    1. Polymorphism at rs11720285, rs11130605 and rs9809315, all of which are located either 5' of the transcription start site or in intron 1 of the FLNB gene has been identified as significantly associated with BMD in Caucasian women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FLNB elisa kitDiseases associated with FLNB elisa kit
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >18 publications with FLNB and Congenital Abnormalities
 Spondylocarpotarsal synostosis Antibodies  >7 publications with FLNB and Spondylocarpotarsal synostosis
 Boomerang dysplasia Antibodies  >6 publications with FLNB and Boomerang dysplasia
 Liver Neoplasms Antibodies  >3 publications with FLNB and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with FLNB and Liver Diseases
 Adenocarcinoma Antibodies  >3 publications with FLNB and Adenocarcinoma
 Nervous System Diseases Antibodies  >3 publications with FLNB and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with FLNB and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >2 publications with FLNB and Cardiovascular Diseases
 ATELOSTEOGENESIS, TYPE III Antibodies  >2 publications with FLNB and ATELOSTEOGENESIS, TYPE III
Organs/Tissues associated with FLNB elisa kit
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with FLNB and Bone
 Connective Tissue Antibodies  >5 publications with FLNB and Connective Tissue
 Heart Antibodies  >4 publications with FLNB and Heart
 Vascular Antibodies  >4 publications with FLNB and Vascular
 Brain Antibodies  >4 publications with FLNB and Brain
 Muscle Antibodies  >3 publications with FLNB and Muscle
 Liver Antibodies  >3 publications with FLNB and Liver
 Embryonic Tissue Antibodies  >2 publications with FLNB and Embryonic Tissue
 Lung Antibodies  >2 publications with FLNB and Lung
 Blood Antibodies  >2 publications with FLNB and Blood
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