P15328.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,819 Da
NCBI Official Full Name
Folate receptor alpha
NCBI Official Synonym Full Names
folate receptor 1 (adult)
NCBI Official Synonym Symbols
NCBI Protein Information
folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
UniProt Protein Name
Folate receptor alpha
UniProt Synonym Protein Names
Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18
UniProt Synonym Gene Names
UniProt Entry Name
FOLR1_HUMAN
NCBI Summary for FOLR1
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for FOLR1
FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11q13.3-q14.1
Cellular Component: anchored to external side of plasma membrane; cell surface; clathrin-coated vesicle; membrane; integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; endosome
Molecular Function: folic acid transporter activity; receptor activity; folic acid binding
Biological Process: receptor-mediated endocytosis; folic acid metabolic process; folic acid transport
Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency
Research Articles on FOLR1
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Products associated with FOLR1 elisa kit
Pathways associated with FOLR1 elisa kit
Diseases associated with FOLR1 elisa kit
Organs/Tissues associated with FOLR1 elisa kit
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