NP_005473.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,252 Da
NCBI Official Full Name
GPI-anchor transamidase
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis, class K
NCBI Official Synonym Symbols
NCBI Protein Information
GPI-anchor transamidase; PIG-K; GPI8 homolog; GPI transamidase subunit; phosphatidylinositol glycan, class K; phosphatidylinositol-glycan biosynthesis class K protein
UniProt Protein Name
GPI-anchor transamidase
UniProt Synonym Protein Names
GPI8 homolog; hGPI8; Phosphatidylinositol-glycan biosynthesis class K protein; PIG-K
UniProt Synonym Gene Names
UniProt Entry Name
GPI8_HUMAN
NCBI Summary for PIGK
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for PIGK
PIGK: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.
Protein type: EC 3.-.-.-; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Protease; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component: endoplasmic reticulum membrane; membrane; integral to endoplasmic reticulum membrane; GPI-anchor transamidase complex
Molecular Function: protein binding; cysteine-type endopeptidase activity; protein disulfide isomerase activity; GPI-anchor transamidase activity
Biological Process: cellular protein metabolic process; protein folding; attachment of GPI anchor to protein; C-terminal protein lipidation; post-translational protein modification; proteolysis
Research Articles on PIGK
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Products associated with PIGK elisa kit
Pathways associated with PIGK elisa kit
Diseases associated with PIGK elisa kit
Organs/Tissues associated with PIGK elisa kit
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