ACZ44929.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
60,959 Da
NCBI Official Full Name
glycoprotein V (platelet)
NCBI Official Synonym Full Names
glycoprotein V (platelet)
NCBI Official Synonym Symbols
NCBI Protein Information
platelet glycoprotein V; glycoprotein 5
UniProt Protein Name
Platelet glycoprotein V
UniProt Synonym Protein Names
Glycoprotein 5
UniProt Synonym Gene Names
UniProt Entry Name
GPV_HUMAN
NCBI Summary for GP5
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
UniProt Comments for GP5
GPV: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: collagen binding
Biological Process: platelet activation; cell-matrix adhesion; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway
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Products associated with GP5 elisa kit
Pathways associated with GP5 elisa kit
Diseases associated with GP5 elisa kit
Organs/Tissues associated with GP5 elisa kit
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