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GH elisa kit :: Goat Growth Hormone Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS011850 GH elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone Antibody (GH), ELISA Kit

 Also Known As   

Goat Growth Hormone Antibody ELISA Kit

 Product Gene Name   

GH elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P19756
 Species Reactivity    Goat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GH purchase    MBS011850 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Hormone Antibody (GH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GH. The ELISA analytical biochemical technique of the MBS011850 kit is based on GH antibody-GH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GH. It may not necessarily be applicable to this product.
 NCBI GI #    114326444
 NCBI GeneID    397488
 NCBI Accession #    NP_999419.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_214254.2 [Other Products]
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 UniProt Primary Accession #    P19756 [Other Products]
 UniProt Related Accession #    P19756 [Other Products]
 Molecular Weight    71,145 Da
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 NCBI Official Full Name    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; somatotropin receptor
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorCleaved into the following chain:Growth hormone-binding protein; GH-binding protein; GHBP; Alternative name(s):; Serum-binding protein
 Protein Family    Envelope glycoprotein
 UniProt Gene Name    GHR [Similar Products]
 UniProt Synonym Gene Names    GH receptor; GH-binding protein; GHBP [Similar Products]
 UniProt Entry Name    GHR_PIG
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 UniProt Comments for GH    Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Subunit structure: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

By similarity. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Note: On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway

By similarity.Growth hormone-binding protein: Secreted

By similarity. Note: Complexed to a substantial fraction of circulating GH

By similarity.

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization

By similarity.

Post-translational modification: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2

By similarity. Ref.2On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization

By similarity.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain.
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 Research Articles on GH    1. the results of this study provide an anatomical basis for GH-R expression in the porcine oviduct during different stages of the oestrus cycle and pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GH elisa kitOrgans/Tissues associated with GH elisa kit
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >405 publications with GH and Liver
 Muscle Antibodies  >148 publications with GH and Muscle
 Brain Antibodies  >126 publications with GH and Brain
 Kidney Antibodies  >92 publications with GH and Kidney
 Adipose Tissue Antibodies  >63 publications with GH and Adipose Tissue
 Embryonic Tissue Antibodies  >47 publications with GH and Embryonic Tissue
 Lung Antibodies  >21 publications with GH and Lung
 Intestine Antibodies  >17 publications with GH and Intestine
 Spleen Antibodies  >17 publications with GH and Spleen
 Skin Antibodies  >16 publications with GH and Skin
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