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ISR elisa kit :: Goat Insulin Receptor (ISR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS264098 ISR elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Receptor (ISR), ELISA Kit

 Also Known As   

Goat Insulin Receptor (ISR) ELISA Kit

 Product Gene Name   

ISR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    610549
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 Species Reactivity    Goat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ISR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ISR purchase    MBS264098 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Insulin Receptor (ISR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ISR. The ELISA analytical biochemical technique of the MBS264098 kit is based on ISR antibody-ISR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ISR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ISR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ISR. It may not necessarily be applicable to this product.
 NCBI GI #    914086
 NCBI GeneID    3643
 NCBI Accession #    AAB33426.1 [Other Products]
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 UniProt Secondary Accession #    Q17RW0; Q59H98; Q9UCB7; Q9UCB8; Q9UCB9 [Other Products]
 UniProt Related Accession #    P06213 [Other Products]
 Molecular Weight    155,146 Da
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 NCBI Official Full Name    insulin receptor, partial
 NCBI Official Synonym Full Names    insulin receptor
 NCBI Official Symbol    INSR [Similar Products]
 NCBI Official Synonym Symbols   
HHF5; CD220
[Similar Products]
 NCBI Protein Information    insulin receptor; IR
 UniProt Protein Name    Insulin receptor
 UniProt Synonym Protein Names   
CD_antigen: CD220Cleaved into the following 2 chains:Insulin receptor subunit alpha; Insulin receptor subunit beta
 UniProt Gene Name    INSR [Similar Products]
 UniProt Synonym Gene Names    IR [Similar Products]
 UniProt Entry Name    INSR_HUMAN
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 NCBI Summary for ISR    After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ISR    INSR: a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). The holoenzyme is cleaved into two chains, the alpha and beta subunits. The active complex is a tetramer containing 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains constitute the ligand- binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Familial mutations associated with insulin resistant diabetes, acanthosis nigricans, pineal hyperplasia, and polycystic ovary syndrome. SNP variants may be associated with polycystic ovary syndrome, atypical migraine and diabetic hyperlipidemia. Mutations also cause leprechaunism, a severe insulin resistance syndrome causing growth retardation and death in early infancy. Two isoforms of the human protein are produced by alternative splicing. The Short isoform has a higher affinity for insulin than the longer. Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta. Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; TK group; InsR family

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: intracellular membrane-bound organelle; membrane; integral to plasma membrane; plasma membrane; endosome membrane; caveola; receptor complex

Molecular Function: insulin binding; insulin-like growth factor receptor binding; protein binding; insulin-like growth factor I binding; GTP binding; insulin receptor substrate binding; protein-tyrosine kinase activity; PTB domain binding; phosphoinositide 3-kinase binding; receptor signaling protein tyrosine kinase activity; insulin-like growth factor II binding; ATP binding; insulin receptor activity

Biological Process: heart morphogenesis; epidermis development; positive regulation of nitric oxide biosynthetic process; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of glycogen biosynthetic process; regulation of embryonic development; exocrine pancreas development; glucose homeostasis; positive regulation of glucose import; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; male sex determination; positive regulation of cell proliferation; protein heterotetramerization; positive regulation of developmental growth; positive regulation of mitosis; activation of protein kinase B; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; cellular response to insulin stimulus; positive regulation of glycolysis; carbohydrate metabolic process; insulin receptor signaling pathway; activation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of DNA replication; positive regulation of cell migration; transformation of host cell by virus

Disease: Diabetes Mellitus, Insulin-resistant, With Acanthosis Nigricans; Hyperinsulinemic Hypoglycemia, Familial, 5; Pineal Hyperplasia, Insulin-resistant Diabetes Mellitus, And Somatic Abnormalities; Donohue Syndrome
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 Research Articles on ISR    1. Different insulin receptor family expression levels were measured in six cancer cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ISR elisa kitPathways associated with ISR elisa kit
 Reference Product  PubMed Publications
 IRS1 elisa kit  >38 publications with ISR and IRS1
 IGF1 elisa kit  >25 publications with ISR and IGF1
 INS elisa kit  >25 publications with ISR and INS
 IRS2 elisa kit  >17 publications with ISR and IRS2
 PIK3R1 elisa kit  >6 publications with ISR and PIK3R1
 PTPN1 elisa kit  >4 publications with ISR and PTPN1
 SHC1 elisa kit  >3 publications with ISR and SHC1
 GRB10 elisa kit  >1 publications with ISR and GRB10
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 IRS Activation Pathway antibodies  IRS Activation Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
Diseases associated with ISR elisa kitOrgans/Tissues associated with ISR elisa kit
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >131 publications with ISR and Insulin Resistance
 Hyperinsulinism Antibodies  >87 publications with ISR and Hyperinsulinism
 Neoplasms Antibodies  >80 publications with ISR and Neoplasms
 Hyperglycemia Antibodies  >24 publications with ISR and Hyperglycemia
 Hypertension Antibodies  >19 publications with ISR and Hypertension
 Breast Neoplasms Antibodies  >15 publications with ISR and Breast Neoplasms
 Diabetes Mellitus, Experimental Antibodies  >14 publications with ISR and Diabetes Mellitus, Experimental
 Brain Diseases Antibodies  >13 publications with ISR and Brain Diseases
 Atherosclerosis Antibodies  >12 publications with ISR and Atherosclerosis
 Inflammation Antibodies  >10 publications with ISR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with ISR and Blood
 Muscle Antibodies  >51 publications with ISR and Muscle
 Liver Antibodies  >50 publications with ISR and Liver
 Brain Antibodies  >44 publications with ISR and Brain
 Ovary Antibodies  >30 publications with ISR and Ovary
 Adipose Tissue Antibodies  >21 publications with ISR and Adipose Tissue
 Pancreas Antibodies  >18 publications with ISR and Pancreas
 Connective Tissue Antibodies  >15 publications with ISR and Connective Tissue
 Vascular Antibodies  >13 publications with ISR and Vascular
 Bone Antibodies  >10 publications with ISR and Bone
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