NP_742151.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,706 Da
NCBI Official Full Name
interferon lambda-3
NCBI Official Synonym Full Names
interferon, lambda 3
NCBI Protein Information
interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)
UniProt Protein Name
Interferon lambda-3
UniProt Synonym Protein Names
Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C
UniProt Synonym Gene Names
UniProt Entry Name
IFNL3_HUMAN
NCBI Summary for IL28B
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
UniProt Comments for IL28B
IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus
Disease: Hepatitis C Virus, Susceptibility To
Research Articles on IL28B
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Products associated with IL28B elisa kit
Pathways associated with IL28B elisa kit
Diseases associated with IL28B elisa kit
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