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IL4 elisa kit :: Goat Interleukin 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS034572 IL4 elisa kit
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 Product Name   

Interleukin 4 (IL4), ELISA Kit

 Also Known As   

Goat Interleukin 4 ELISA Kit

 Product Gene Name   

IL4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 5; NC_000005.9 (132009678..132018370). Location: 5q31.1
 OMIM    147780
 3D Structure    ModBase 3D Structure for P05112
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 Species Reactivity    Goat
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Sandwich
 Detection Range    6.25pg/ml-200pg/ml.
 Sensitivity    The sensitivity of this kit is 1.0pg/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IL4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IL4 purchase    MBS034572 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin 4 (IL4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25pg/ml-200pg/ml in biological research samples containing IL4, with an estimated sensitivity of The sensitivity of this kit is 1.0pg/ml. The ELISA analytical biochemical technique of the MBS034572 kit is based on IL4 antibody-IL4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IL4 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of IL4 (hereafter termed "analyte") in undiluted original Goat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS034572. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IL4. It may not necessarily be applicable to this product.
 NCBI GI #    4504669
 NCBI GeneID    3565
 NCBI Accession #    NP_000580.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000589.3 [Other Products]
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 UniProt Primary Accession #    P05112 [Other Products]
 UniProt Secondary Accession #    Q14630 [Other Products]
 UniProt Related Accession #    P05112 [Other Products]
 Molecular Weight    17,492 Da
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 NCBI Official Full Name    interleukin-4 isoform 1
 NCBI Official Synonym Full Names    interleukin 4
 NCBI Official Symbol    IL4 [Similar Products]
 NCBI Official Synonym Symbols   
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
[Similar Products]
 NCBI Protein Information    interleukin-4; binetrakin; pitrakinra; B cell growth factor 1; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1
 UniProt Protein Name    Interleukin-4
 UniProt Synonym Protein Names   
B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
 Protein Family    Interleukin
 UniProt Gene Name    IL4 [Similar Products]
 UniProt Synonym Gene Names    IL-4; BSF-1 [Similar Products]
 UniProt Entry Name    IL4_HUMAN
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 NCBI Summary for IL4    The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL4    IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Cell cycle regulation; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: protein binding; growth factor activity; cytokine activity; interleukin-4 receptor binding

Biological Process: regulation of isotype switching; negative regulation of osteoclast differentiation; positive regulation of isotype switching to IgG isotypes; positive regulation of transcription, DNA-dependent; regulation of proton transport; microglial cell activation; female pregnancy; chemotaxis; positive regulation of activated T cell proliferation; response to organic cyclic substance; positive regulation of isotype switching to IgE isotypes; positive regulation of interleukin-10 production; B cell costimulation; connective tissue growth factor biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interleukin-13 production; negative regulation of macrophage activation; response to nutrient; response to drug; cholesterol metabolic process; regulation of immune response; negative regulation of chronic inflammatory response; T-helper 2 type immune response; regulation of phosphorylation; B cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of acute inflammatory response; defense response to protozoan; T-helper 1 cell lineage commitment; response to ethanol; positive regulation of chemokine biosynthetic process; innate immune response in mucosa; positive regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat5 protein; retina development in camera-type eye; B cell differentiation; response to cytokine stimulus; cellular defense response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; immune response; T-helper 2 cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of defense response to virus by host; negative regulation of apoptosis

Disease: Stroke, Ischemic
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 Research Articles on IL4    1. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL4 elisa kitPathways associated with IL4 elisa kit
 Reference Product  PubMed Publications
 IL5 elisa kit  >183 publications with IL4 and IL5
 STAT6 elisa kit  >89 publications with IL4 and STAT6
 IL4R elisa kit  >63 publications with IL4 and IL4R
 IL13RA1 elisa kit  >15 publications with IL4 and IL13RA1
 CSF2 elisa kit  >14 publications with IL4 and CSF2
 JAK2 elisa kit  >10 publications with IL4 and JAK2
 JAK3 elisa kit  >8 publications with IL4 and JAK3
 IL2RG elisa kit  >3 publications with IL4 and IL2RG
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with IL4 elisa kitOrgans/Tissues associated with IL4 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >275 publications with IL4 and Necrosis
 Hypersensitivity Antibodies  >268 publications with IL4 and Hypersensitivity
 Inflammation Antibodies  >262 publications with IL4 and Inflammation
 Hypersensitivity, Immediate Antibodies  >214 publications with IL4 and Hypersensitivity, Immediate
 Asthma Antibodies  >188 publications with IL4 and Asthma
 Lung Diseases Antibodies  >178 publications with IL4 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >161 publications with IL4 and Respiratory Hypersensitivity
 Autoimmune Diseases Antibodies  >157 publications with IL4 and Autoimmune Diseases
 Liver Diseases Antibodies  >47 publications with IL4 and Liver Diseases
 Cardiovascular Diseases Antibodies  >46 publications with IL4 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1117 publications with IL4 and Blood
 Spleen Antibodies  >96 publications with IL4 and Spleen
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