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CHRM2 elisa kit :: Goat M2-Cholinergic Receptor Antibodies ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021228 CHRM2 elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M2-Cholinergic Receptor Antibodies (CHRM2), ELISA Kit

 Also Known As   

Goat M2-Cholinergic Receptor Antibodies ELISA Kit

 Product Gene Name   

CHRM2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P10980
 Species Reactivity    Goat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CHRM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CHRM2 purchase    MBS021228 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the M2-Cholinergic Receptor Antibodies (CHRM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CHRM2. The ELISA analytical biochemical technique of the MBS021228 kit is based on CHRM2 antibody-CHRM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CHRM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CHRM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CHRM2. It may not necessarily be applicable to this product.
 NCBI GI #    13591922
 NCBI GeneID    81645
 NCBI Accession #    NP_112278.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031016.1 [Other Products]
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 UniProt Primary Accession #    P10980 [Other Products]
 UniProt Secondary Accession #    Q9Z2Z1 [Other Products]
 UniProt Related Accession #    P10980 [Other Products]
 Molecular Weight    51,539 Da
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 NCBI Official Full Name    muscarinic acetylcholine receptor M2
 NCBI Official Synonym Full Names    cholinergic receptor, muscarinic 2
 NCBI Official Symbol    Chrm2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    muscarinic acetylcholine receptor M2; 7TM receptor; muscarinic receptor m2; M2 muscarinic acetylcholine receptor; cholinergic receptor, muscarinic 2, cardiac
 UniProt Protein Name    Muscarinic acetylcholine receptor M2
 Protein Family    Muscarinic acetylcholine receptor
 UniProt Gene Name    Chrm2 [Similar Products]
 UniProt Synonym Gene Names    Chrm-2 [Similar Products]
 UniProt Entry Name    ACM2_RAT
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 NCBI Summary for CHRM2    may inhibit cholinergic-mediated bronchoconstriction; may regulate bladder contraction [RGD, Feb 2006]
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 UniProt Comments for CHRM2    mAChR M2: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD). MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Cellular Component: asymmetric synapse; postsynaptic membrane; membrane; cell soma; integral to plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction

Molecular Function: drug binding; G-protein coupled acetylcholine receptor activity

Biological Process: regulation of smooth muscle contraction; synaptic transmission; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); acetylcholine receptor signaling, muscarinic pathway; response to virus; regulation of heart contraction
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 Research Articles on CHRM2    1. Hyperglycemia caused a higher expression of M2-muscarinic receptors in cardiomyocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CHRM2 elisa kitPathways associated with CHRM2 elisa kit
 Reference Product  PubMed Publications
 Chrm4 elisa kit  >4 publications with CHRM2 and Chrm4
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with CHRM2 elisa kit
 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >23 publications with CHRM2 and Substance-Related Disorders
 Inflammation Antibodies  >4 publications with CHRM2 and Inflammation
 Death Antibodies  >4 publications with CHRM2 and Death
 Nervous System Diseases Antibodies  >3 publications with CHRM2 and Nervous System Diseases
 Cognition Disorders Antibodies  >3 publications with CHRM2 and Cognition Disorders
 Memory Disorders Antibodies  >3 publications with CHRM2 and Memory Disorders
 Immune System Diseases Antibodies  >2 publications with CHRM2 and Immune System Diseases
 Liver Diseases Antibodies  >1 publications with CHRM2 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with CHRM2 and Kidney Diseases
 Weight Loss Antibodies  >1 publications with CHRM2 and Weight Loss
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