AAI25210.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
110,509 Da
NCBI Official Full Name
Oncostatin M receptor
NCBI Official Synonym Full Names
oncostatin M receptor
NCBI Official Synonym Symbols
NCBI Protein Information
oncostatin-M-specific receptor subunit beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit
UniProt Protein Name
Oncostatin-M-specific receptor subunit beta
UniProt Synonym Protein Names
Interleukin-31 receptor subunit beta
UniProt Synonym Gene Names
OSMRB; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB [Similar Products]
UniProt Entry Name
OSMR_HUMAN
NCBI Summary for OSMR
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Comments for OSMR
OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: oncostatin-M receptor complex
Molecular Function: oncostatin-M receptor activity; growth factor binding
Biological Process: positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation
Disease: Amyloidosis, Primary Localized Cutaneous, 1
Research Articles on OSMR
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Products associated with OSMR elisa kit
Pathways associated with OSMR elisa kit
Diseases associated with OSMR elisa kit
Organs/Tissues associated with OSMR elisa kit
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