CAG46480.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,344 Da
NCBI Official Full Name
PGDS
NCBI Official Synonym Full Names
hematopoietic prostaglandin D synthase
NCBI Protein Information
hematopoietic prostaglandin D synthase; GST class-sigma; prostaglandin-H2 D-isomerase; glutathione S-transferase sigma; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; hematopoietic prostaglandin D2 synthase; glutathione-requiring prostaglandin D synthase
UniProt Protein Name
Hematopoietic prostaglandin D synthase
UniProt Synonym Protein Names
GST class-sigma; Glutathione S-transferase (EC:2.5.1.18); Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase
UniProt Synonym Gene Names
UniProt Entry Name
HPGDS_HUMAN
NCBI Summary for PGDS
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PGDS
Ptgds2: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family.
Protein type: Isomerase; Lipid Metabolism - arachidonic acid; EC 2.5.1.18; EC 5.3.99.2
Chromosomal Location of Human Ortholog: 4q22.3
Cellular Component: cytoplasm; cytosol
Molecular Function: protein homodimerization activity; prostaglandin-D synthase activity; glutathione transferase activity; magnesium ion binding; calcium ion binding
Biological Process: xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; locomotory behavior; signal transduction; prostaglandin metabolic process
Research Articles on PGDS
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Products associated with PGDS elisa kit
Pathways associated with PGDS elisa kit
Diseases associated with PGDS elisa kit
Organs/Tissues associated with PGDS elisa kit
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