NP_001026.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
564,567 Da
NCBI Official Full Name
ryanodine receptor 2
NCBI Official Synonym Full Names
ryanodine receptor 2 (cardiac)
NCBI Official Synonym Symbols
RyR; ARVC2; ARVD2; RYR-2; VTSIP [Similar Products]
NCBI Protein Information
ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel
UniProt Protein Name
Ryanodine receptor 2
UniProt Synonym Protein Names
Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
UniProt Synonym Gene Names
UniProt Entry Name
RYR2_HUMAN
NCBI Summary for RYR2
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for RYR2
RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.
Protein type: Transporter; Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; membrane; sarcoplasmic reticulum; plasma membrane; Z disc
Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity
Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; response to redox state; positive regulation of heart rate; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; BMP signaling pathway; cellular calcium ion homeostasis; release of sequestered calcium ion into cytosol; calcium ion transport; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction
Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2
Research Articles on RYR2
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Products associated with RYR2 elisa kit
Pathways associated with RYR2 elisa kit
Diseases associated with RYR2 elisa kit
Disease Name |
Pubmed Publications |
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies |
>18365 publications with RYR2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY |
Heart Diseases Antibodies |
>946 publications with RYR2 and Heart Diseases |
Arrhythmias, Cardiac Antibodies |
>552 publications with RYR2 and Arrhythmias, Cardiac |
Nervous System Diseases Antibodies |
>445 publications with RYR2 and Nervous System Diseases |
Heart Failure Antibodies |
>436 publications with RYR2 and Heart Failure |
Tachycardia Antibodies |
>345 publications with RYR2 and Tachycardia |
Tachycardia, Ventricular Antibodies |
>328 publications with RYR2 and Tachycardia, Ventricular |
Disease Models, Animal Antibodies |
>230 publications with RYR2 and Disease Models, Animal |
Cardiomyopathies Antibodies |
>150 publications with RYR2 and Cardiomyopathies |
Cardiomegaly Antibodies |
>109 publications with RYR2 and Cardiomegaly |
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