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SIGMAR1 elisa kit :: Goat SIgMa Non-Opioid Intracellular Receptor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005565 SIGMAR1 elisa kit
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 Product Name   

SIgMa Non-Opioid Intracellular Receptor 1 (SIGMAR1), ELISA Kit

 Also Known As   

Goat SIgMa Non-Opioid Intracellular Receptor 1 ELISA Kit

 Product Gene Name   

SIGMAR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 9; NC_000009.11 (34634719..34637768, complement). Location: 9p13.3
 OMIM    601978
 3D Structure    ModBase 3D Structure for Q99720
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 Species Reactivity    Goat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SIGMAR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SIGMAR1 purchase    MBS005565 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SIgMa Non-Opioid Intracellular Receptor 1 (SIGMAR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SIGMAR1. The ELISA analytical biochemical technique of the MBS005565 kit is based on SIGMAR1 antibody-SIGMAR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SIGMAR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SIGMAR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SIGMAR1. It may not necessarily be applicable to this product.
 NCBI GI #    22212934
 NCBI GeneID    10280
 NCBI Accession #    NP_671513.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_147157.1 [Other Products]
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 UniProt Primary Accession #    Q99720 [Other Products]
 UniProt Secondary Accession #    O00673; O00725; Q0Z9W6; Q153Z1; Q2TSD1; Q53GN2; Q7Z653; Q8N7H3; Q9NYX0; D3DRM7 [Other Products]
 UniProt Related Accession #    Q99720 [Other Products]
 Molecular Weight    25,128 Da
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 NCBI Official Full Name    sigma non-opioid intracellular receptor 1 isoform 2
 NCBI Official Synonym Full Names    sigma non-opioid intracellular receptor 1
 NCBI Official Symbol    SIGMAR1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    sigma non-opioid intracellular receptor 1; SR-BP; SIG-1R; sigma1R; hSigmaR1; SR31747 binding protein 1; sigma 1-type opioid receptor; aging-associated gene 8 protein
 UniProt Protein Name    Sigma non-opioid intracellular receptor 1
 UniProt Synonym Protein Names   
Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor
 Protein Family    Sigma non-opioid intracellular receptor
 UniProt Gene Name    SIGMAR1 [Similar Products]
 UniProt Synonym Gene Names    OPRS1; SRBP; SR-BP; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1 [Similar Products]
 UniProt Entry Name    SGMR1_HUMAN
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 NCBI Summary for SIGMAR1    This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2008]
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 UniProt Comments for SIGMAR1    SIGMAR1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Defects in SIGMAR1 are the cause of amyotrophic lateral sclerosis type 16, juvenile (ALS16). ALS16 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Belongs to the ERG2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear envelope; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; growth cone; integral to plasma membrane; integral to membrane; nuclear inner membrane; nuclear envelope; lipid particle; cell junction

Molecular Function: opioid receptor activity; drug binding

Biological Process: nervous system development; regulation of neuron apoptosis; lipid transport

Disease: Amyotrophic Lateral Sclerosis 16, Juvenile
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 Research Articles on SIGMAR1    1. coding and noncoding variants located in the 3'-UTR region of the SIGMAR1 gene are not the cause of FTLD-MND in our cohort, and more than half of this targeted cohort is genetically explained by C9ORF72 repeat expansions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with SIGMAR1 elisa kitOrgans/Tissues associated with SIGMAR1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with SIGMAR1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with SIGMAR1 and Brain Diseases
 Central Nervous System Diseases Antibodies  >8 publications with SIGMAR1 and Central Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with SIGMAR1 and Disease Models, Animal
 Nerve Degeneration Antibodies  >2 publications with SIGMAR1 and Nerve Degeneration
 Liver Diseases Antibodies  >1 publications with SIGMAR1 and Liver Diseases
 Cognition Disorders Antibodies  >1 publications with SIGMAR1 and Cognition Disorders
 Depressive Disorder Antibodies  >1 publications with SIGMAR1 and Depressive Disorder
 Weight Loss Antibodies  >1 publications with SIGMAR1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >12 publications with SIGMAR1 and Eye
 Brain Antibodies  >12 publications with SIGMAR1 and Brain
 Blood Antibodies  >4 publications with SIGMAR1 and Blood
 Liver Antibodies  >2 publications with SIGMAR1 and Liver
 Muscle Antibodies  >1 publications with SIGMAR1 and Muscle
 Kidney Antibodies  >1 publications with SIGMAR1 and Kidney
 Placenta Antibodies  >1 publications with SIGMAR1 and Placenta
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