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PLA2R1 Ab elisa kit :: Goat Secretory phospholipase A2 receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2603437 PLA2R1 Ab elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Secretory phospholipase A2 receptor (PLA2R1 Ab), ELISA Kit

 Also Known As   

Goat Secretory phospholipase A2 receptor antibody (PLA2R1 Ab) ELISA Kit

 Product Gene Name   

PLA2R1 Ab elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604939
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 Species Reactivity    Goat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PLA2R1 Ab elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PLA2R1 Ab purchase    MBS2603437 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Secretory phospholipase A2 receptor (PLA2R1 Ab) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PLA2R1 Ab. The ELISA analytical biochemical technique of the MBS2603437 kit is based on PLA2R1 Ab antibody-PLA2R1 Ab antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLA2R1 Ab antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLA2R1 Ab. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PLA2R1 Ab. It may not necessarily be applicable to this product.
 NCBI GI #    307548857
 NCBI GeneID    22925
 NCBI Accession #    NP_001182570.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195641.1 [Other Products]
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 UniProt Secondary Accession #    Q13019; Q15095; Q53R45; Q53RR7; B2RTU9; D3DPB1 [Other Products]
 UniProt Related Accession #    Q13018 [Other Products]
 Molecular Weight    152,805 Da
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 NCBI Official Full Name    secretory phospholipase A2 receptor isoform 3
 NCBI Official Synonym Full Names    phospholipase A2 receptor 1
 NCBI Official Symbol    PLA2R1 [Similar Products]
 NCBI Official Synonym Symbols   
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
[Similar Products]
 NCBI Protein Information    secretory phospholipase A2 receptor
 UniProt Protein Name    Secretory phospholipase A2 receptor
 UniProt Synonym Protein Names   
180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor
 Protein Family    Secretory phospholipase A2 receptor
 UniProt Gene Name    PLA2R1 [Similar Products]
 UniProt Synonym Gene Names    CLEC13C; PLA2-R; PLA2R; Soluble PLA2-R; Soluble PLA2R [Similar Products]
 UniProt Entry Name    PLA2R_HUMAN
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 NCBI Summary for PLA2R1 Ab    This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
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 UniProt Comments for PLA2R1 Ab    PLA2R1: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: cell surface; extracellular region; integral to membrane; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: carbohydrate binding; phospholipase binding; receptor activity

Biological Process: cytokine production; endocytosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; receptor-mediated endocytosis
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 Research Articles on PLA2R1 Ab    1. Case Report: PLA2R positive membranous nephropathy in kidney transplant recipient with both IgA nephropathy and HCV infection long after kidney transplant from identical twin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLA2R1 Ab elisa kitPathways associated with PLA2R1 Ab elisa kit
 Reference Product  PubMed Publications
 PLA2G10 elisa kit  >4 publications with PLA2R1 Ab and PLA2G10
 PLA2G1B elisa kit  >3 publications with PLA2R1 Ab and PLA2G1B
 MYC elisa kit  >2 publications with PLA2R1 Ab and MYC
 PLA2G2A elisa kit  >2 publications with PLA2R1 Ab and PLA2G2A
 PLA2G2D elisa kit  >1 publications with PLA2R1 Ab and PLA2G2D
 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with PLA2R1 Ab elisa kitOrgans/Tissues associated with PLA2R1 Ab elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >59 publications with PLA2R1 Ab and Kidney Diseases
 Proteinuria Antibodies  >17 publications with PLA2R1 Ab and Proteinuria
 Inflammation Antibodies  >15 publications with PLA2R1 Ab and Inflammation
 Necrosis Antibodies  >6 publications with PLA2R1 Ab and Necrosis
 Disease Models, Animal Antibodies  >5 publications with PLA2R1 Ab and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >2 publications with PLA2R1 Ab and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with PLA2R1 Ab and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >2 publications with PLA2R1 Ab and Adenocarcinoma
 Hyperplasia Antibodies  >1 publications with PLA2R1 Ab and Hyperplasia
 Fibrosis Antibodies  >1 publications with PLA2R1 Ab and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >32 publications with PLA2R1 Ab and Kidney
 Blood Antibodies  >28 publications with PLA2R1 Ab and Blood
 Muscle Antibodies  >6 publications with PLA2R1 Ab and Muscle
 Pancreas Antibodies  >5 publications with PLA2R1 Ab and Pancreas
 Lung Antibodies  >5 publications with PLA2R1 Ab and Lung
 Ovary Antibodies  >4 publications with PLA2R1 Ab and Ovary
 Vascular Antibodies  >3 publications with PLA2R1 Ab and Vascular
 Placenta Antibodies  >2 publications with PLA2R1 Ab and Placenta
 Brain Antibodies  >2 publications with PLA2R1 Ab and Brain
 Embryonic Tissue Antibodies  >2 publications with PLA2R1 Ab and Embryonic Tissue
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