P86176.1
[Other Products]
UniProt Related Accession #
Molecular Weight
26,959 Da
NCBI Official Full Name
T-cell immunoreceptor with Ig and ITIM domains
NCBI Official Synonym Full Names
T cell immunoreceptor with Ig and ITIM domains
NCBI Protein Information
T-cell immunoreceptor with Ig and ITIM domains
UniProt Protein Name
T-cell immunoreceptor with Ig and ITIM domains
UniProt Synonym Protein Names
V-set and transmembrane domain-containing protein 3
UniProt Entry Name
TIGIT_MOUSE
UniProt Comments for TIGIT
TIGIT: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: cell surface; cell-cell adherens junction; integral to plasma membrane
Molecular Function: cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; negative regulation of interleukin-12 production; negative regulation of T cell activation; positive regulation of interleukin-10 production
Research Articles on TIGIT
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Products associated with TIGIT elisa kit
Pathways associated with TIGIT elisa kit
Organs/Tissues associated with TIGIT elisa kit
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