Q0VD83.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
114,874 Da
NCBI Official Full Name
Apolipoprotein B receptor
NCBI Official Synonym Full Names
apolipoprotein B receptor
NCBI Protein Information
apolipoprotein B receptor; apoB-48R; apolipoprotein B48 receptor; apolipoprotein B-48 receptor; apolipoprotein B100 receptor; apolipoprotein B-100 receptor
UniProt Protein Name
Apolipoprotein B receptor
UniProt Synonym Protein Names
Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor
UniProt Synonym Gene Names
UniProt Entry Name
APOBR_HUMAN
NCBI Summary for AHA
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for AHA
APOB48R: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 16p11
Cellular Component: chylomicron; membrane; plasma membrane
Molecular Function: very-low-density lipoprotein receptor activity
Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; triacylglycerol metabolic process; lipid transport
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