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BCAR1 elisa kit :: Goose Breast Cancer Estrogen Resistance 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS094868 BCAR1 elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Breast Cancer Estrogen Resistance 1 (BCAR1), ELISA Kit

 Also Known As   

Goose Breast Cancer Estrogen Resistance 1 ELISA Kit

 Product Gene Name   

BCAR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604704
 3D Structure    ModBase 3D Structure for O75815
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 Species Reactivity    Goose
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BCAR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BCAR1 purchase    MBS094868 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Breast Cancer Estrogen Resistance 1 (BCAR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BCAR1. The ELISA analytical biochemical technique of the MBS094868 kit is based on BCAR1 antibody-BCAR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BCAR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BCAR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for BCAR1. It may not necessarily be applicable to this product.
 NCBI GI #    4502371
 NCBI GeneID    8412
 NCBI Accession #    NP_003558.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003567.3 [Other Products]
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 UniProt Primary Accession #    O75815 [Other Products]
 UniProt Secondary Accession #    Q5TEW3; Q6UW40; Q9BR50; D3DT43 [Other Products]
 UniProt Related Accession #    O75815 [Other Products]
 Molecular Weight    92,566 Da
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 NCBI Official Full Name    breast cancer anti-estrogen resistance protein 3 isoform 1
 NCBI Official Synonym Full Names    breast cancer anti-estrogen resistance 3
 NCBI Official Symbol    BCAR3 [Similar Products]
 NCBI Official Synonym Symbols   
NSP2; SH2D3B
[Similar Products]
 NCBI Protein Information    breast cancer anti-estrogen resistance protein 3; novel SH2-containing protein 2; SH2 domain-containing protein 3B; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
 UniProt Protein Name    Breast cancer anti-estrogen resistance protein 3
 UniProt Synonym Protein Names   
Novel SH2-containing protein 2; SH2 domain-containing protein 3B
 Protein Family    Breast cancer anti-estrogen resistance protein
 UniProt Gene Name    BCAR3 [Similar Products]
 UniProt Synonym Gene Names    NSP2; SH2D3B [Similar Products]
 UniProt Entry Name    BCAR3_HUMAN
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 NCBI Summary for BCAR1    Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for BCAR1    BCAR3: a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.

Protein type: GEFs, Ras; Adaptor/scaffold; GEFs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p22.1

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity

Biological Process: response to drug; small GTPase mediated signal transduction; lens morphogenesis in camera-type eye; signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of GTPase activity
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 Research Articles on BCAR1    1. BCAR1 and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BCAR1 elisa kitPathways associated with BCAR1 elisa kit
 Reference Product  PubMed Publications
 BCAR1 elisa kit  >21 publications with BCAR1 and BCAR1
 SRC elisa kit  >14 publications with BCAR1 and SRC
 CDC42 elisa kit  >5 publications with BCAR1 and CDC42
 EGFR elisa kit  >3 publications with BCAR1 and EGFR
 NEDD9 elisa kit  >3 publications with BCAR1 and NEDD9
 RRAS elisa kit  >2 publications with BCAR1 and RRAS
 ESR1 elisa kit  >1 publications with BCAR1 and ESR1
 IRS1 elisa kit  >1 publications with BCAR1 and IRS1
 Products by Pathway  Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
Diseases associated with BCAR1 elisa kitOrgans/Tissues associated with BCAR1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >26 publications with BCAR1 and Neoplasms
 Breast Neoplasms Antibodies  >20 publications with BCAR1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with BCAR1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >2 publications with BCAR1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >2 publications with BCAR1 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >2 publications with BCAR1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >2 publications with BCAR1 and Disease Models, Animal
 Endometrial Neoplasms Antibodies  >1 publications with BCAR1 and Endometrial Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with BCAR1 and Prenatal Exposure Delayed Effects
 Necrosis Antibodies  >1 publications with BCAR1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with BCAR1 and Blood
 Kidney Antibodies  >2 publications with BCAR1 and Kidney
 Lymph Node Antibodies  >2 publications with BCAR1 and Lymph Node
 Testis Antibodies  >1 publications with BCAR1 and Testis
 Mouth Antibodies  >1 publications with BCAR1 and Mouth
 Ovary Antibodies  >1 publications with BCAR1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with BCAR1 and Embryonic Tissue
 Eye Antibodies  >1 publications with BCAR1 and Eye
 Connective Tissue Antibodies  >1 publications with BCAR1 and Connective Tissue
 Mammary Gland Antibodies  >1 publications with BCAR1 and Mammary Gland
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