NP_000441.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,655 Da
NCBI Official Full Name
E-selectin
NCBI Official Synonym Full Names
selectin E
NCBI Official Synonym Symbols
ELAM; ESEL; CD62E; ELAM1; LECAM2 [Similar Products]
NCBI Protein Information
E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
UniProt Protein Name
E-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2
UniProt Synonym Gene Names
UniProt Entry Name
LYAM2_HUMAN
NCBI Summary for E-SELECTIN
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for E-SELECTIN
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q22-q25
Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; plasma membrane; integral to membrane; coated pit; caveola; lipid raft
Molecular Function: protein binding; transmembrane receptor activity; phospholipase binding; sialic acid binding
Biological Process: positive regulation of leukocyte migration; actin filament-based process; positive regulation of receptor internalization; calcium-mediated signaling; response to lipopolysaccharide; leukocyte migration during inflammatory response; heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; regulation of inflammatory response; inflammatory response; blood coagulation; leukocyte tethering or rolling; leukocyte migration
Disease: Hypertension, Essential
Research Articles on E-SELECTIN
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Products associated with E-SELECTIN elisa kit
Pathways associated with E-SELECTIN elisa kit
Diseases associated with E-SELECTIN elisa kit
Organs/Tissues associated with E-SELECTIN elisa kit
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