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FAK elisa kit :: Goose Focal Adhesion Kinase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS030215 FAK elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Focal Adhesion Kinase (FAK), ELISA Kit

 Also Known As   

Goose Focal Adhesion Kinase ELISA Kit

 Product Gene Name   

FAK elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 8; NC_000008.10 (141668481..142011412, complement). Location: 8q24.3
 OMIM    600758
 3D Structure    ModBase 3D Structure for Q05397
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FAK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FAK purchase    MBS030215 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Focal Adhesion Kinase (FAK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FAK. The ELISA analytical biochemical technique of the MBS030215 kit is based on FAK antibody-FAK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FAK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FAK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for FAK. It may not necessarily be applicable to this product.
 NCBI GI #    439875
 NCBI GeneID    5747
 NCBI Accession #    AAA58469.1 [Other Products]
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 UniProt Primary Accession #    Q05397 [Other Products]
 UniProt Secondary Accession #    Q14291; Q9UD85; B4E2N6; F5H4S4 [Other Products]
 UniProt Related Accession #    Q05397 [Other Products]
 Molecular Weight    119,233 Da
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 NCBI Official Full Name    focal adhesion kinase
 NCBI Official Synonym Full Names    protein tyrosine kinase 2
 NCBI Official Symbol    PTK2 [Similar Products]
 NCBI Official Synonym Symbols   
FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
[Similar Products]
 NCBI Protein Information    focal adhesion kinase 1; FADK 1; PTK2 protein tyrosine kinase 2; FAK-related non-kinase polypeptide; focal adhesion kinase-related nonkinase; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71
 UniProt Protein Name    Focal adhesion kinase 1
 UniProt Synonym Protein Names   
Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK
 Protein Family    Focal adhesion kinase
 UniProt Gene Name    PTK2 [Similar Products]
 UniProt Synonym Gene Names    FAK; FAK1; FADK 1; FRNK; PPP1R71 [Similar Products]
 UniProt Entry Name    FAK1_HUMAN
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 NCBI Summary for FAK    This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
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 UniProt Comments for FAK    FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; Protein kinase, TK; TK group; Fak family

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; focal adhesion; lamellipodium; apical plasma membrane; cytoplasm; plasma membrane; stress fiber; microtubule organizing center; cell cortex; nucleus; cytosol

Molecular Function: JUN kinase binding; protein binding; signal transducer activity; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; SH2 domain binding; actin binding; protein kinase binding; ATP binding; receptor binding; protein kinase activity

Biological Process: heart morphogenesis; axon guidance; extracellular matrix organization and biogenesis; establishment of nucleus localization; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; neuron migration; cell motility involved in cell locomotion; negative regulation of synaptogenesis; regulation of cell shape; regulation of cell adhesion mediated by integrin; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; ephrin receptor signaling pathway; negative regulation of axonogenesis; angiogenesis; vasculogenesis; cell structure disassembly during apoptosis; placenta development; integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; central nervous system neuron axonogenesis; regulation of osteoblast differentiation; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; negative regulation of organ growth; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; embryonic development; establishment of cell polarity; positive regulation of protein kinase activity; regulation of focal adhesion formation; innate immune response; endothelial cell migration; negative regulation of cell-cell adhesion; positive regulation of protein amino acid phosphorylation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis; positive regulation of cell migration; regulation of cytoskeleton organization and biogenesis
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 Research Articles on FAK    1. FAK knockdown and re-expression assays showed that FAK activity selectively promoted anchorage-independent ID8-IP cell survival. These results support the continued evaluation of FAK inhibitors as a promising clinical treatment for ovarian cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FAK elisa kitPathways associated with FAK elisa kit
 Reference Product  PubMed Publications
 SRC elisa kit  >577 publications with FAK and SRC
 PXN elisa kit  >350 publications with FAK and PXN
 CRK elisa kit  >151 publications with FAK and CRK
 BCAR1 elisa kit  >102 publications with FAK and BCAR1
 FYN elisa kit  >69 publications with FAK and FYN
 GRB2 elisa kit  >60 publications with FAK and GRB2
 PTPN11 elisa kit  >25 publications with FAK and PTPN11
 TGFB1I1 elisa kit  >10 publications with FAK and TGFB1I1
 TLN1 elisa kit  >3 publications with FAK and TLN1
 ITGB3 elisa kit  >3 publications with FAK and ITGB3
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with FAK elisa kitOrgans/Tissues associated with FAK elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >766 publications with FAK and Neoplasms
 Neoplasm Invasiveness Antibodies  >177 publications with FAK and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >155 publications with FAK and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >119 publications with FAK and Breast Neoplasms
 Adenocarcinoma Antibodies  >117 publications with FAK and Adenocarcinoma
 Lung Diseases Antibodies  >77 publications with FAK and Lung Diseases
 Neoplasms, Experimental Antibodies  >76 publications with FAK and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >74 publications with FAK and Lung Neoplasms
 Liver Diseases Antibodies  >72 publications with FAK and Liver Diseases
 Liver Neoplasms Antibodies  >70 publications with FAK and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >360 publications with FAK and Vascular
 Blood Antibodies  >310 publications with FAK and Blood
 Muscle Antibodies  >225 publications with FAK and Muscle
 Brain Antibodies  >162 publications with FAK and Brain
 Kidney Antibodies  >150 publications with FAK and Kidney
 Lung Antibodies  >127 publications with FAK and Lung
 Bone Antibodies  >118 publications with FAK and Bone
 Liver Antibodies  >113 publications with FAK and Liver
 Embryonic Tissue Antibodies  >94 publications with FAK and Embryonic Tissue
 Heart Antibodies  >84 publications with FAK and Heart
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