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GRN elisa kit :: Goose Granulin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS007043 GRN elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Granulin (GRN), ELISA Kit

 Also Known As   

Goose Granulin ELISA Kit

 Product Gene Name   

GRN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 17; NC_000017.10 (42422491..42430470). Location: 17q21.32
 OMIM    138945
 3D Structure    ModBase 3D Structure for P28799
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 Species Reactivity    Goose
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GRN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GRN purchase    MBS007043 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Granulin (GRN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRN. The ELISA analytical biochemical technique of the MBS007043 kit is based on GRN antibody-GRN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GRN. It may not necessarily be applicable to this product.
 NCBI GI #    183613
 NCBI GeneID    2896
 NCBI Accession #    AAA58617.1 [Other Products]
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 UniProt Primary Accession #    P28799 [Other Products]
 UniProt Secondary Accession #    P23781; P23782; P23783; P23784; Q53Y88; Q540U8; Q9BWE7; Q9UCH0; D3DX55 [Other Products]
 UniProt Related Accession #    P28799 [Other Products]
 Molecular Weight    63,544 Da
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 NCBI Official Full Name    granulin
 NCBI Official Synonym Full Names    granulin
 NCBI Official Symbol    GRN [Similar Products]
 NCBI Official Synonym Symbols   
GEP; GP88; PEPI; PGRN; CLN11; PCDGF
[Similar Products]
 NCBI Protein Information    granulins; acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor
 UniProt Protein Name    Granulins
 UniProt Synonym Protein Names   
Proepithelin; PEPICleaved into the following 9 chains:AcrograninParagranulinGranulin-1; Alternative name(s):; Granulin GGranulin-2; Alternative name(s):; Granulin FGranulin-3; Alternative name(s):; Granulin BGranulin-4; Alternative name(s):; Granulin AGranulin-5; Alternative name(s):; Granulin CGranulin-6; Alternative name(s):; Granulin DGranulin-7; Alternative name(s):; Granulin E
 Protein Family    Granulin
 UniProt Gene Name    GRN [Similar Products]
 UniProt Synonym Gene Names    PEPI [Similar Products]
 UniProt Entry Name    GRN_HUMAN
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 NCBI Summary for GRN    Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRN    GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: extracellular space; mitochondrion; intracellular membrane-bound organelle

Molecular Function: protein binding; growth factor activity; cytokine activity

Biological Process: blastocyst hatching; signal transduction; positive regulation of epithelial cell proliferation; embryo implantation

Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11
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 Research Articles on GRN    1. Patients with GRN A9D mutations are diagnosed with amyotrophic lateral sclerosis, atypical extrapyramidal disorder and frontotemporal dementia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRN elisa kitPathways associated with GRN elisa kit
 Reference Product  PubMed Publications
 CHMP2B elisa kit  >26 publications with GRN and CHMP2B
 TARDBP elisa kit  >12 publications with GRN and TARDBP
 VEGFA elisa kit  >5 publications with GRN and VEGFA
 SLPI elisa kit  >5 publications with GRN and SLPI
 CCND1 elisa kit  >3 publications with GRN and CCND1
 MMP12 elisa kit  >1 publications with GRN and MMP12
 CCNT1 elisa kit  >1 publications with GRN and CCNT1
 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with GRN elisa kitOrgans/Tissues associated with GRN elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >299 publications with GRN and Nervous System Diseases
 Dementia Antibodies  >296 publications with GRN and Dementia
 Brain Diseases Antibodies  >275 publications with GRN and Brain Diseases
 Frontotemporal Lobar Degeneration Antibodies  >244 publications with GRN and Frontotemporal Lobar Degeneration
 Frontotemporal Dementia Antibodies  >217 publications with GRN and Frontotemporal Dementia
 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED Antibodies  >216 publications with GRN and FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED
 Neoplasms Antibodies  >83 publications with GRN and Neoplasms
 Inflammation Antibodies  >52 publications with GRN and Inflammation
 Nerve Degeneration Antibodies  >30 publications with GRN and Nerve Degeneration
 Necrosis Antibodies  >21 publications with GRN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >217 publications with GRN and Brain
 Blood Antibodies  >119 publications with GRN and Blood
 Nerve Antibodies  >55 publications with GRN and Nerve
 Vascular Antibodies  >29 publications with GRN and Vascular
 Embryonic Tissue Antibodies  >28 publications with GRN and Embryonic Tissue
 Liver Antibodies  >24 publications with GRN and Liver
 Muscle Antibodies  >23 publications with GRN and Muscle
 Heart Antibodies  >22 publications with GRN and Heart
 Bone Antibodies  >21 publications with GRN and Bone
 Lung Antibodies  >15 publications with GRN and Lung
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