NP_001120972.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
155,541 Da
NCBI Official Full Name
hepatocyte growth factor receptor isoform a
NCBI Official Synonym Full Names
met proto-oncogene
NCBI Protein Information
hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
UniProt Protein Name
Hepatocyte growth factor receptor
UniProt Synonym Protein Names
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
UniProt Synonym Gene Names
UniProt Entry Name
MET_HUMAN
NCBI Summary for HGFR
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HGFR
Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.
Protein type: Protein kinase, TK; Oncoprotein; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Met family
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: cell surface; integral to plasma membrane; basal plasma membrane; plasma membrane; integral to membrane; extracellular region
Molecular Function: protein binding; protein-tyrosine kinase activity; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding
Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; muscle cell migration; myotube differentiation; hepatocyte growth factor receptor signaling pathway; signal transduction; liver development; glucose homeostasis; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; endothelial cell morphogenesis; brain development; placenta development
Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1
Research Articles on HGFR
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Products associated with HGFR elisa kit
Pathways associated with HGFR elisa kit
Diseases associated with HGFR elisa kit
Organs/Tissues associated with HGFR elisa kit
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